caa a22 4500 606174583 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1731-z doi (NATIONALLICENCE)springer-10.1007/s00018-014-1731-z Tools of the trade: podosomes as multipurpose organelles of monocytic cells [Elektronische Daten] [Stefan Linder, Christiane Wiesner] Podosomes are adhesion and invasion structures that are particularly prominent in cells of the monocytic lineage such as macrophages, dendritic cells, and osteoclasts. They are multifunctional organelles that combine several key abilities required for cell migration and invasion. The podosome repertoire includes well-established functions such as cell-substrate adhesion, and extracellular matrix degradation, recently discovered abilities such as rigidity and topology sensing as well as antigen sampling, and also more speculative functions such as cell protrusion stabilization and transmigration. Collectively, podosomes not only enable dynamic interactions of cells with their surroundings, they also gather information about the pericellular environment, and are actively involved in its reshaping. This review presents an overview of the current knowledge on podosome composition, architecture, and regulation. We focus in particular on the growing list of podosome functions and discuss the specific properties of podosomes in macrophages, dendritic cells, and osteoclasts. Moreover, this article highlights podosome-related intracellular transport processes, the formation of podosomes in 3D environments as well as potentially podosome-associated diseases involving monocytic cells. Springer Basel, 2014 Actin nationallicence Dendritic cells nationallicence Extracellular matrix nationallicence Macrophages nationallicence Matrix metalloproteinases nationallicence Microtubules nationallicence Osteoclasts nationallicence ADAM : A disintegrin and metalloproteinase nationallicence Arp : Actin-related protein nationallicence CD : Cluster of differentiation nationallicence ECM : Extracellular matrix nationallicence FMNL : Formin-like nationallicence HDAC : Histone deacetylase nationallicence KIF : Kinesin-like nationallicence LAD : Leukocyte adhesion deficiency nationallicence MMP : Matrix metalloproteinase nationallicence MT1-MMP : Membrane-type 1-matrix metalloproteinase nationallicence PAPA : Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (syndrome) nationallicence PSTPIP : Proline-serine-threonine phosphatase interacting protein nationallicence PMA : Phorbol 12-myristate 13-acetate nationallicence SZ : Sealing zone nationallicence TAM : Tumor-associated macrophage nationallicence WAS : Wiskott-Aldrich syndrome nationallicence WASP : Wiskott-Aldrich syndrome protein nationallicence Linder Stefan Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Wiesner Christiane Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 121-135 1420-682X 72:1<121 2015 72 18 https://doi.org/10.1007/s00018-014-1731-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1731-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Linder Stefan Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Wiesner Christiane Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 121-135 1420-682X 72:1<121 2015 72 18