caa a22 4500 606174605 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1710-4 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1710-4 Tumor-derived exosomes in oncogenic reprogramming and cancer progression [Elektronische Daten] [Sarmad Saleem, Asim Abdel-Mageed] In multicellular organisms, effective communication between cells is a crucial part of cellular and tissue homeostasis. This communication mainly involves direct cell-cell contact as well as the secretion of molecules that bind to receptors at the recipient cells. However, a more recently characterized mode of intercellular communication—the release of membrane vesicles known as exosomes—has been the subject of increasing interest and intensive research over the past decade. Following the discovery of the exosome-mediated immune activation, the pathophysiological roles of exosomes have been recognized in different diseases, including cancer. In this review, we describe the biogenesis and main physical characteristics that define exosomes as a specific population of secreted vesicles, with a special focus on their role in oncogenic transformation and cancer progression. Springer Basel, 2014 Extracellular vesicles nationallicence Tumor microenvironment nationallicence Signaling nationallicence Oncogenic reprogramming nationallicence Mesenchymal stem cells nationallicence Metastasis nationallicence Saleem Sarmad Department of Urology, Tulane University School of Medicine, SL-42, 1430 Tulane Avenue, LA 70112, New Orleans, USA aut Abdel-Mageed Asim Department of Urology, Tulane University School of Medicine, SL-42, 1430 Tulane Avenue, LA 70112, New Orleans, USA aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 1-10 1420-682X 72:1<1 2015 72 18 https://doi.org/10.1007/s00018-014-1710-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1710-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saleem Sarmad Department of Urology, Tulane University School of Medicine, SL-42, 1430 Tulane Avenue, LA 70112, New Orleans, USA aut NATIONALLICENCE 700 1- Abdel-Mageed Asim Department of Urology, Tulane University School of Medicine, SL-42, 1430 Tulane Avenue, LA 70112, New Orleans, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 1-10 1420-682X 72:1<1 2015 72 18