caa a22 4500 606174621 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1729-6 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1729-6 Mechanisms of developmental neurite pruning [Elektronische Daten] [Oren Schuldiner, Avraham Yaron] The precise wiring of the nervous system is a combined outcome of progressive and regressive events during development. Axon guidance and synapse formation intertwined with cell death and neurite pruning sculpt the mature circuitry. It is now well recognized that pruning of dendrites and axons as means to refine neuronal networks, is a wide spread phenomena required for the normal development of vertebrate and invertebrate nervous systems. Here we will review the arising principles of cellular and molecular mechanisms of neurite pruning. We will discuss these principles in light of studies in multiple neuronal systems, and speculate on potential explanations for the emergence of neurite pruning as a mechanism to sculpt the nervous system. Springer Basel, 2014 Neuronal remodeling nationallicence Axon pruning nationallicence Axon degeneration nationallicence Neurodevelopment nationallicence ALS : Amyotrophic lateral sclerosis nationallicence BDNF : Brain derived neurotrophic factor nationallicence CRMPs : Collapsin response mediator proteins nationallicence CST : Corticospinal tract nationallicence da : Dendritic arborization nationallicence dLGN : Dorsal lateral geniculate nucleus nationallicence DRG : Dorsal root ganglia nationallicence EcR : Ecdysone receptor nationallicence GAP : GTPase activating protein nationallicence GEF : GTP exchange factor nationallicence IPB : Infrapyramidal bundle nationallicence MARCM : Mosaic analysis with a repressible cell marker nationallicence MB : Mushroom body nationallicence MTs : Microtubules nationallicence NFs : Neurofilaments nationallicence NGF : Nerve growth factor nationallicence NMJ : Neuromuscular junction nationallicence PS : Phosphatidylserine nationallicence RGCs : Retinal ganglion cells nationallicence SC : Superior colliculus nationallicence SCG : Superior cervical ganglion nationallicence TGF-β : Transforming growth factor-β nationallicence UPS : Ubituitin proteasome System nationallicence WD : Wallerian degeneration nationallicence Schuldiner Oren Department of Molecular Cell Biology, Weizmann Institute of Sciences, 7610001, Rehovot, Israel aut Yaron Avraham Department of Biological Chemistry, Weizmann Institute of Sciences, 7610001, Rehovot, Israel aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 101-119 1420-682X 72:1<101 2015 72 18 https://doi.org/10.1007/s00018-014-1729-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1729-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schuldiner Oren Department of Molecular Cell Biology, Weizmann Institute of Sciences, 7610001, Rehovot, Israel aut NATIONALLICENCE 700 1- Yaron Avraham Department of Biological Chemistry, Weizmann Institute of Sciences, 7610001, Rehovot, Israel aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 101-119 1420-682X 72:1<101 2015 72 18