caa a22 4500 60617463X CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1712-2 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1712-2 Schröder Katrin Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NADPH oxidases in bone homeostasis and osteoporosis [Elektronische Daten] [Katrin Schröder] Bone formation and degradation are perfectly coordinated. In case of an imbalance of these processes diseases occur associated with exaggerated formation of new bone or bone loss as in osteoporosis. Most studies investigating osteoporosis either focus on osteoblast or osteoclast function and differentiation. Both processes have been suggested to be affected by reactive oxygen species (ROS). Besides a potentially harmful role of ROS, these small molecules are important second messengers. The family of NADPH oxidases produces ROS in a controlled and targeted manner, to specifically regulate signal transduction. This review will highlight the role of reactive oxygen species in bone cell differentiation and bone-loss associated disease with a special focus on osteoporosis and NADPH oxidases as specialized sources of ROS. Springer Basel, 2014 NADPH oxidase nationallicence Reactive oxygen species nationallicence Nox nationallicence Bone nationallicence Osteoclasts nationallicence Osteoblasts nationallicence Osteoporosis nationallicence Steap : Six-transmembrane epithelial antigen of prostate nationallicence IL : Interleukin nationallicence TNF : Tumour necrosis factor nationallicence IFN : Interferon nationallicence TGF : Transforming growth factor nationallicence NAC : N-acetyl-cysteine nationallicence RANK : Receptor activator of nuclear factor (NF)-κB-receptor nationallicence RANKL : Receptor activator of NF-κB ligand nationallicence OPG : Osteoprotegerin nationallicence BMP-2 : Bone morphogenic protein 2 nationallicence Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 25-38 1420-682X 72:1<25 2015 72 18 https://doi.org/10.1007/s00018-014-1712-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1712-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Schröder Katrin Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der Goethe-Universität, Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 25-38 1420-682X 72:1<25 2015 72 18