caa a22 4500 606174656 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1714-0 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1714-0 What does genetics tell us about imprinting and the placenta connection? [Elektronische Daten] [Susannah Varmuza, Kamelia Miri] Genomic imprinting is an epigenetic gene silencing phenomenon that is specific to eutherians in the vertebrate lineage. The acquisition of both placentation and genomic imprinting has spurred interest in the possible evolutionary link for many years. In this review we examine the genetic evidence and find that while many imprinted domains are anchored by genes required for proper placenta development in a parent of origin fashion, an equal number of imprinted genes have no apparent function that depends on imprinting. Examination of recent data from studies of molecular and genetic mechanisms points to a maternal control of the selection and maintenance of imprint marks, reinforcing the importance of the oocyte in the healthy development of the placenta and fetus. Springer Basel, 2014 Genomic imprinting nationallicence Placentation nationallicence Maternal effect nationallicence Differential methylation nationallicence Targeted mutation nationallicence Conflict hypothesis nationallicence Trophoblast nationallicence Oocyte nationallicence Varmuza Susannah Department of Cell and Systems Biology, University of Toronto, 611-25 Harbord Street, M5S 3G5, Toronto, Canada aut Miri Kamelia Department of Cell and Systems Biology, University of Toronto, 611-25 Harbord Street, M5S 3G5, Toronto, Canada aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 51-72 1420-682X 72:1<51 2015 72 18 https://doi.org/10.1007/s00018-014-1714-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1714-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Varmuza Susannah Department of Cell and Systems Biology, University of Toronto, 611-25 Harbord Street, M5S 3G5, Toronto, Canada aut NATIONALLICENCE 700 1- Miri Kamelia Department of Cell and Systems Biology, University of Toronto, 611-25 Harbord Street, M5S 3G5, Toronto, Canada aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 51-72 1420-682X 72:1<51 2015 72 18