caa a22 4500 606174664 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1711-3 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1711-3 Centriolar satellites: key mediators of centrosome functions [Elektronische Daten] [Maxim Tollenaere, Niels Mailand, Simon Bekker-Jensen] Centriolar satellites are small, microscopically visible granules that cluster around centrosomes. These structures, which contain numerous proteins directly involved in centrosome maintenance, ciliogenesis, and neurogenesis, have traditionally been viewed as vehicles for protein trafficking towards the centrosome. However, the recent identification of several new centriolar satellite components suggests that this model offers only an incomplete picture of their cellular functions. While the mechanisms controlling centriolar satellite status and function are not yet understood in detail, emerging evidence points to these structures as important hubs for dynamic, multi-faceted regulation in response to a variety of cues. In this review, we summarize the current knowledge of the roles of centriolar satellites in regulating centrosome functions, ciliogenesis, and neurogenesis. We also highlight newly discovered regulatory mechanisms targeting centriolar satellites and their functional status, and we discuss how defects in centriolar satellite components are intimately linked to a wide spectrum of human diseases. Springer Basel, 2014 Centriolar satellites nationallicence Centrosome nationallicence Ciliogenesis nationallicence Neurogenesis nationallicence PCM1 nationallicence Protein transport nationallicence Tollenaere Maxim Faculty of Health Sciences, Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark aut Mailand Niels Faculty of Health Sciences, Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark aut Bekker-Jensen Simon Faculty of Health Sciences, Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 11-23 1420-682X 72:1<11 2015 72 18 https://doi.org/10.1007/s00018-014-1711-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1711-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tollenaere Maxim Faculty of Health Sciences, Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Mailand Niels Faculty of Health Sciences, Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Bekker-Jensen Simon Faculty of Health Sciences, Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 11-23 1420-682X 72:1<11 2015 72 18