caa a22 4500 606174702 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1921-3 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1921-3 Adrenomedullin in lymphangiogenesis: from development to disease [Elektronische Daten] [Klara Klein, Kathleen Caron] Over the past decade, we have begun to appreciate that the lymphatic vascular system does more than simply return plasma back into the circulatory system and, in fact, contributes to a wide variety of normal and disease states. For this reason, much research has been devoted to understanding how lymphatic vessels form and function, with a particular interest in which molecules contribute to lymphatic vessel growth and maintenance. In the following review, we focus on a potent lymphangiogenic factor, adrenomedullin, and its known roles in lymphangiogenesis, lymphatic function, and human lymphatic disease. As one of the first, pharmacologically tractable G protein-coupled receptor pathways characterized in lymphatic endothelial cells, the continued study of adrenomedullin effects on the lymphatic system may open new avenues for the modulation of lymphatic growth and function in a variety of lymphatic-related diseases that currently have few treatments. Springer Basel, 2015 Lymphedema nationallicence Calcitonin receptor-like receptor (CLR=protein nationallicence Calcrl =gene) nationallicence Receptor activity modifying protein (RAMP) nationallicence CXCR7 nationallicence Klein Klara Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, CB # 7545, 6312B MBRB, 111 Mason Farm Road, 27599, Chapel Hill, NC, USA aut Caron Kathleen Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, CB # 7545, 6312B MBRB, 111 Mason Farm Road, 27599, Chapel Hill, NC, USA aut Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3115-3126 1420-682X 72:16<3115 2015 72 18 https://doi.org/10.1007/s00018-015-1921-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1921-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Klein Klara Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, CB # 7545, 6312B MBRB, 111 Mason Farm Road, 27599, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Caron Kathleen Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, CB # 7545, 6312B MBRB, 111 Mason Farm Road, 27599, Chapel Hill, NC, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3115-3126 1420-682X 72:16<3115 2015 72 18