caa a22 4500 606174729 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1884-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1884-4 Food odors trigger an endocrine response that affects food ingestion and metabolism [Elektronische Daten] [Oleh Lushchak, Mikael Carlsson, Dick Nässel] Food odors stimulate appetite and innate food-seeking behavior in hungry animals. The smell of food also induces salivation and release of gastric acid and insulin. Conversely, sustained odor exposure may induce satiation. We demonstrate novel effects of food odors on food ingestion, metabolism and endocrine signaling in Drosophila melanogaster. Acute exposure to attractive vinegar odor triggers a rapid and transient increase in circulating glucose, and a rapid upregulation of genes encoding the glucagon-like hormone adipokinetic hormone (AKH), four insulin-like peptides (DILPs) and some target genes in peripheral tissues. Sustained exposure to food odors, however, decreases food intake. Hunger-induced strengthening of synaptic signaling from olfactory sensory neurons (OSNs) to brain neurons increases food-seeking behavior, and conversely fed flies display reduced food odor sensitivity and feeding. We show that increasing the strength of OSN signaling chronically by genetic manipulation of local peptide neuromodulation reduces feeding, elevates carbohydrates and diminishes lipids. Furthermore, constitutively strengthened odor sensitivity altered gene transcripts for AKH, DILPs and some of their targets. Thus, we show that food odor can induce a transient anticipatory endocrine response, and that boosted sensitivity to this odor affects food intake, as well as metabolism and hormonal signaling. Springer Basel, 2015 Insulin-like peptides nationallicence Adipokinetic hormone nationallicence Neuropeptides nationallicence Olfactory sensory neurons nationallicence Feeding nationallicence Drosophila melanogaster nationallicence Lushchak Oleh Department of Zoology, Stockholm University, 10691, Stockholm, Sweden aut Carlsson Mikael Department of Zoology, Stockholm University, 10691, Stockholm, Sweden aut Nässel Dick Department of Zoology, Stockholm University, 10691, Stockholm, Sweden aut Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3143-3155 1420-682X 72:16<3143 2015 72 18 https://doi.org/10.1007/s00018-015-1884-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1884-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lushchak Oleh Department of Zoology, Stockholm University, 10691, Stockholm, Sweden aut NATIONALLICENCE 700 1- Carlsson Mikael Department of Zoology, Stockholm University, 10691, Stockholm, Sweden aut NATIONALLICENCE 700 1- Nässel Dick Department of Zoology, Stockholm University, 10691, Stockholm, Sweden aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3143-3155 1420-682X 72:16<3143 2015 72 18