caa a22 4500 606174761 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1911-5 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1911-5 Natural killer cell heterogeneity: cellular dysfunction and significance in HIV-1 immuno-pathogenesis [Elektronische Daten] [A. Ansari, Fareed Ahmad, Dirk Meyer-Olson, Adeeba Kamarulzaman, Roland Jacobs, Reinhold Schmidt] Natural killer (NK) cells are innate immune effectors that provide first line of defence against viruses. Human NK cells are heterogeneous in nature, and their functions rely on a dynamic balance between germ-line-encoded activating and inhibitory receptors. HIV-1 infection results in altered NK cell receptor repertoire and impaired effector functions including the ability to lyse virus-infected cells and secretion of antiviral cytokine IFN-γ. Over the last decade, additional NK cell subset-specific molecules have been identified, leading to emergence of a more complex cellular diversity than previously thought. Herein, we discuss NK cell subset redistribution, altered receptor repertoire and influence of interaction of polymorphic leucocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIR) on HIV-1 disease progression. Springer Basel, 2015 Innate immunity nationallicence CD56 dim and bright nationallicence Granzyme B nationallicence Antibody-dependent cellular cytotoxicity nationallicence Highly active antiretroviral therapy nationallicence Ansari A. Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Ahmad Fareed Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Meyer-Olson Dirk Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Kamarulzaman Adeeba Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Lambah Pantai, 50603, Kuala Lumpur, Malaysia aut Jacobs Roland Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Schmidt Reinhold Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3037-3049 1420-682X 72:16<3037 2015 72 18 https://doi.org/10.1007/s00018-015-1911-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1911-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ansari A. Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Ahmad Fareed Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Meyer-Olson Dirk Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Kamarulzaman Adeeba Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Lambah Pantai, 50603, Kuala Lumpur, Malaysia aut NATIONALLICENCE 700 1- Jacobs Roland Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Schmidt Reinhold Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3037-3049 1420-682X 72:16<3037 2015 72 18