caa a22 4500 606174818 CHVBK 20210128100739.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00018-015-1917-z doi (NATIONALLICENCE)springer-10.1007/s00018-015-1917-z Atg1 family kinases in autophagy initiation [Elektronische Daten] [Nobuo Noda, Yuko Fujioka] Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy. The Author(s), 2015 Atg1 complex nationallicence ULK1 complex nationallicence Atg13 nationallicence Atg17 nationallicence FIP200 nationallicence Kinase domain nationallicence MIT domain nationallicence AIM : Atg8-family interacting motif nationallicence AKA : Aurora kinase A nationallicence AMPK : AMP-activated protein kinase nationallicence HORMA : Hop1p, Rev7p, and Mad2 nationallicence IDR : Intrinsically disordered region nationallicence KD : Kinase domain nationallicence LIR : LC3-interacting region nationallicence MIM : MIT-interacting motif nationallicence MIT : Microtubule interacting and transport nationallicence mTORC1 : Mammalian TORC1 nationallicence PAS : Pre-autophagosomal structure nationallicence PE : Phosphatidylethanolamine nationallicence PI3K : Phosphatidylinositol 3-kinase nationallicence PKA : Protein kinase A nationallicence TORC1 : TOR kinase complex 1 nationallicence ULK1 : Unc-51-like kinase 1 nationallicence Noda Nobuo Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, Japan aut Fujioka Yuko Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3083-3096 1420-682X 72:16<3083 2015 72 18 https://doi.org/10.1007/s00018-015-1917-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1917-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Noda Nobuo Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujioka Yuko Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/16(2015-08-01), 3083-3096 1420-682X 72:16<3083 2015 72 18