caa a22 4500 606174877 CHVBK 20210128100740.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00018-015-1942-y doi (NATIONALLICENCE)springer-10.1007/s00018-015-1942-y Repression of somatic cell fate in the germline [Elektronische Daten] [Valérie Robert, Steve Garvis, Francesca Palladino] Germ cells must transmit genetic information across generations, and produce gametes while also maintaining the potential to form all cell types after fertilization. Preventing the activation of somatic programs is, therefore, crucial to the maintenance of germ cell identity. Studies in Caenorhabditis elegans, Drosophila melanogaster, and mouse have revealed both similarities and differences in how somatic gene expression is repressed in germ cells, thereby preventing their conversion into somatic tissues. This review will focus on recent developments in our understanding of how global or gene-specific transcriptional repression, chromatin regulation, and translational repression operate in the germline to maintain germ cell identity and repress somatic differentiation programs. Springer Basel, 2015 Reprogramming nationallicence Totipotency nationallicence Differentiation nationallicence Polar granules nationallicence Histones nationallicence Teratoma nationallicence PGCs : Primordial germ cells nationallicence RBPs : RNA-binding proteins nationallicence E : Embryonic day nationallicence BMP : Bone morphogenetic protein nationallicence RNA Pol II : RNA polymerase II nationallicence CTD : C-terminal domain nationallicence Ser2 : Serine2 nationallicence GSC : Germline stem cells nationallicence MAPK : Mitogen-activated protein kinase nationallicence DTC : Distal tip cell nationallicence EGA : Embryonic gene activation nationallicence Robert Valérie Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France aut Garvis Steve Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France aut Palladino Francesca Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France aut Cellular and Molecular Life Sciences Springer Basel 72/19(2015-10-01), 3599-3620 1420-682X 72:19<3599 2015 72 18 https://doi.org/10.1007/s00018-015-1942-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1942-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Robert Valérie Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France aut NATIONALLICENCE 700 1- Garvis Steve Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France aut NATIONALLICENCE 700 1- Palladino Francesca Ecole Normale Supérieure de Lyon, Université de Lyon, 46 allée d'Italie, 69007, Lyon, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/19(2015-10-01), 3599-3620 1420-682X 72:19<3599 2015 72 18