caa a22 4500 606174885 CHVBK 20210128100740.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00018-015-1953-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1953-8 Cell segregation in the vertebrate hindbrain: a matter of boundaries [Elektronische Daten] [Javier Terriente, Cristina Pujades] Segregating cells into compartments during embryonic development is essential for growth and pattern formation. In the developing hindbrain, boundaries separate molecularly, physically and neuroanatomically distinct segments called rhombomeres. After rhombomeric cells have acquired their identity, interhombomeric boundaries restrict cell intermingling between adjacent rhombomeres and act as signaling centers to pattern the surrounding tissue. Several works have stressed the relevance of Eph/ephrin signaling in rhombomeric cell sorting. Recent data have unveiled the role of this pathway in the assembly of actomyosin cables as an important mechanism for keeping cells from different rhombomeres segregated. In this Review, we will provide a short summary of recent evidences gathered in different systems suggesting that physical actomyosin barriers can be a general mechanism for tissue separation. We will discuss current evidences supporting a model where cell-cell signaling pathways, such as Eph/ephrin, govern compartmental cell sorting through modulation of the actomyosin cytoskeleton and cell adhesive properties to prevent cell intermingling. Springer Basel, 2015 Hindbrain segmentation nationallicence Compartments nationallicence Boundaries nationallicence Tissue separation nationallicence Cell sorting nationallicence Cell segregation nationallicence ADAM10 : A disintegrin and metalloproteinase domain-containing protein 10 nationallicence AP : Anteroposterior nationallicence DV : Dorsoventral nationallicence CNS : Central nervous system nationallicence Cadh2 : Cadherin 2 nationallicence Cyp26 : Cytochrome p450 family 26 enzymes nationallicence EphA4MO/ephrinB2Amo : EphA4/ephrinB2a-morphants nationallicence FGF : Fibroblast growth factor nationallicence GEFs : Guanine nucleotide exchange factors nationallicence GAPs : GTPase-activating proteins nationallicence HoxPG1 : Hox paralogous group 1 genes nationallicence MHB : Mid-hindbrain boundary nationallicence RA : Retinoic acid nationallicence Terriente Javier Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Dr Aiguader 88, 08003, Barcelona, Spain aut Pujades Cristina Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Dr Aiguader 88, 08003, Barcelona, Spain aut Cellular and Molecular Life Sciences Springer Basel 72/19(2015-10-01), 3721-3730 1420-682X 72:19<3721 2015 72 18 https://doi.org/10.1007/s00018-015-1953-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1953-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terriente Javier Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Dr Aiguader 88, 08003, Barcelona, Spain aut NATIONALLICENCE 700 1- Pujades Cristina Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, Dr Aiguader 88, 08003, Barcelona, Spain aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/19(2015-10-01), 3721-3730 1420-682X 72:19<3721 2015 72 18