caa a22 4500 606174990 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00018-014-1788-8 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1788-8 p600/UBR4 in the central nervous system [Elektronische Daten] [Kari Parsons, Yoshihiro Nakatani, Minh Nguyen] A decade ago, the large 600kDa mammalian protein p600 (also known as UBR4) was discovered as a multifunctional protein with roles in anoikis, viral transformation and protein degradation. Recently, p600 has emerged as a critical protein in the mammalian brain with roles in neurogenesis, neuronal migration, neuronal signaling and survival. How p600 integrates these apparently unrelated functions to maintain tissue homeostasis and murine survival remains unclear. The common molecular basis underlying many of the actions of p600 suggests, however, certain conservation and transposition of these functions across systems. In this review, we summarize the central nervous system functions of p600 and propose new perspectives on its biological complexity in neuronal physiology and neurological diseases. Springer Basel, 2014 p600 nationallicence UBR4 nationallicence CNS nationallicence Brain nationallicence Neurons nationallicence Neurological diseases nationallicence a.a. : Amino acid nationallicence ASD : Autism spectrum disorder nationallicence BPV-1 : Bovine papillomavirus type 1 nationallicence Ca2+ : Calcium nationallicence CaM : Calmodulin nationallicence CaMKIIα : CaM-dependent protein Kinase II α isoform nationallicence CNS : Central nervous system nationallicence ER : Endoplasmic reticulum nationallicence FAK : Focal adhesion kinase nationallicence hCALO : Human homologue of Calossin nationallicence HPV-16 : Human papillomavirus type 16 nationallicence MT : Microtubule nationallicence N-cadherin : Neuronal cadherin nationallicence p600 : Protein 600 nationallicence RB : Retinoblastoma protein nationallicence RBAF600 : Retinoblastoma-associated factor of 600kDa nationallicence Ub : Ubiquitin nationallicence UBR4 : Ubiquitin protein ligase E3 component N-recognin 4 nationallicence ZUBR1 : Zinc finger UBR1 type 1 nationallicence Parsons Kari Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 3330 Hospital Drive NW, T2N 4N1, Calgary, Canada aut Nakatani Yoshihiro Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA aut Nguyen Minh Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 3330 Hospital Drive NW, T2N 4N1, Calgary, Canada aut Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1149-1160 1420-682X 72:6<1149 2015 72 18 https://doi.org/10.1007/s00018-014-1788-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1788-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parsons Kari Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 3330 Hospital Drive NW, T2N 4N1, Calgary, Canada aut NATIONALLICENCE 700 1- Nakatani Yoshihiro Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Nguyen Minh Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, 3330 Hospital Drive NW, T2N 4N1, Calgary, Canada aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1149-1160 1420-682X 72:6<1149 2015 72 18