caa a22 4500 606175024 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00018-014-1779-9 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1779-9 Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex [Elektronische Daten] [Ting Ban, Jian-Kang Zhu, Karsten Melcher, H. Xu] RNA-binding proteins play crucial roles in RNA processing and function as regulators of gene expression. Recent studies have defined the structural basis for RNA recognition by diverse RNA-binding motifs. While many RNA-binding proteins recognize RNA sequence non-specifically by associating with 5′ or 3′ RNA ends, sequence-specific recognition by RNA-binding proteins is typically achieved by combining multiple modular domains to form complex binding surfaces. In this review, we present examples of structures from different classes of RNA-binding proteins, identify the mechanisms utilized by them to target specific RNAs, and describe structural principles of how protein-protein interactions affect RNA recognition specificity. We also highlight the structural mechanism of sequence-dependent and -independent interactions in the Cas9-RNA-DNA complex. Springer Basel, 2014 RNA recognition nationallicence RNA-binding protein nationallicence Tandem repeat module nationallicence Sequence-specific recognition nationallicence Protein-protein interaction nationallicence PPR : Pentatricopeptide repeat nationallicence Pre-mRNA : Precursor messenger RNA nationallicence RBDs : RNA-binding domains nationallicence TPR : Tetratricopeptide repeat nationallicence PUF : Pumilio-FBF nationallicence TZF : TTP-like zinc finger nationallicence AGO : Argonaute-like nationallicence FBF : fem-3 binding factor nationallicence ssRNA : Single-stranded RNA nationallicence TTP : Tristetraprolin nationallicence PIWI : P-element-induced wimpy testes nationallicence PAZ : PIWI, Argonaute, and Zwille nationallicence MDA5 : Melanoma differentiation-associated gene 5 nationallicence RIG-I : Retinoic acid-inducible gene I nationallicence PPP-RNA : 5′ triphosphate RNA nationallicence RRM : RNA recognition motif nationallicence U2AF : U2 auxiliary factor nationallicence hnRNP : Heterogeneous nuclear ribonucleoprotein nationallicence CRISPR : Clustered regularly interspaced short palindromic repeats nationallicence Ban Ting Roche Innovation Center Shanghai, 720 Cailun Road, 201203, Shanghai, People's Republic of China aut Zhu Jian-Kang Shanghai Center for Plant Stress Biology and Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, 200032, Shanghai, China aut Melcher Karsten Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Ave., N.E, 49503, Grand Rapids, MI, USA aut Xu H. VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China aut Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1045-1058 1420-682X 72:6<1045 2015 72 18 https://doi.org/10.1007/s00018-014-1779-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1779-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ban Ting Roche Innovation Center Shanghai, 720 Cailun Road, 201203, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Zhu Jian-Kang Shanghai Center for Plant Stress Biology and Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, 200032, Shanghai, China aut NATIONALLICENCE 700 1- Melcher Karsten Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Ave., N.E, 49503, Grand Rapids, MI, USA aut NATIONALLICENCE 700 1- Xu H. VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1045-1058 1420-682X 72:6<1045 2015 72 18