caa a22 4500 606175040 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00018-014-1768-z doi (NATIONALLICENCE)springer-10.1007/s00018-014-1768-z Bloch-Gallego Evelyne Institut Cochin, INSERM U. 1016, CNRS UMR 8104, University Paris Descartes 24, rue du Fbg St-Jacques, 75014, Paris, France aut Mechanisms controlling neuromuscular junction stability [Elektronische Daten] [Evelyne Bloch-Gallego] The neuromuscular junction (NMJ) is the synaptic connection between motor neurons and muscle fibers. It is involved in crucial processes such as body movements and breathing. Its proper development requires the guidance of motor axons toward their specific targets, the development of multi-innervated myofibers, and a selective synapse stabilization. It first consists of the removal of excessive motor axons on myofibers, going from multi-innervation to a single innervation of each myofiber. Whereas guidance cues of motor axons toward their specific muscular targets are well characterized, only few molecular and cellular cues have been reported as clues for selecting and stabilizing specific neuromuscular junctions. We will first provide a brief summary on NMJ development. We will then review molecular cues that are involved in NMJ stabilization, in both pre- and post-synaptic compartments, considering motor neurons and Schwann cells on the one hand, and muscle on the other hand. We will provide links with pathologies and highlight advances that can be brought both by basic research on NMJ development and clinical data resulting from the analyses of neurodegeneration of synaptic connections to obtain a better understanding of this process. The goal of this review is to highlight the findings toward understanding the roles of poly- or single-innervations and the underlying mechanisms of NMJ stabilization. European Union, 2014 Motor neuron nationallicence Axon development nationallicence Axon retraction nationallicence Stability nationallicence Neuromuscular junction nationallicence Synapse nationallicence Polyinnervation nationallicence Agrin nationallicence Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1029-1043 1420-682X 72:6<1029 2015 72 18 https://doi.org/10.1007/s00018-014-1768-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1768-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bloch-Gallego Evelyne Institut Cochin, INSERM U. 1016, CNRS UMR 8104, University Paris Descartes 24, rue du Fbg St-Jacques, 75014, Paris, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1029-1043 1420-682X 72:6<1029 2015 72 18