caa a22 4500 606175067 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00018-014-1782-1 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1782-1 Viral genes as oncolytic agents for cancer therapy [Elektronische Daten] [Shishir Gupta, Ravi Gandham, A. Sahoo, A. Tiwari] Many viruses have the ability to modulate the apoptosis, and to accomplish it; viruses encode proteins which specifically interact with the cellular signaling pathways. While some viruses encode proteins, which inhibit the apoptosis or death of the infected cells, there are viruses whose encoded proteins can kill the infected cells by multiple mechanisms, including apoptosis. A particular class of these viruses has specific gene(s) in their genomes which, upon ectopic expression, can kill the tumor cells selectively without affecting the normal cells. These genes and their encoded products have demonstrated great potential to be developed as novel anticancer therapeutic agents which can specifically target and kill the cancer cells leaving the normal cells unharmed. In this review, we will discuss about the viral genes having specific cancer cell killing properties, what is known about their functioning, signaling pathways and their therapeutic applications as anticancer agents. Springer Basel, 2014 Apoptosis nationallicence Anticancer genes nationallicence Cancer nationallicence Gene therapy nationallicence Chicken infectious anemia nationallicence Apoptin nationallicence VP3 nationallicence Parvovirus nationallicence NS1 nationallicence Adenovirus nationallicence E4orf4 nationallicence B19PV nationallicence MVM nationallicence H-1PV nationallicence CPV nationallicence Gupta Shishir Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut Gandham Ravi Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut Sahoo A. Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut Tiwari A. Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1073-1094 1420-682X 72:6<1073 2015 72 18 https://doi.org/10.1007/s00018-014-1782-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1782-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gupta Shishir Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut NATIONALLICENCE 700 1- Gandham Ravi Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut NATIONALLICENCE 700 1- Sahoo A. Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut NATIONALLICENCE 700 1- Tiwari A. Molecular Biology Lab, Division of Veterinary Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, UP, India aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1073-1094 1420-682X 72:6<1073 2015 72 18