caa a22 4500 606175075 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00018-014-1780-3 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1780-3 Accumulating evidence for a role of oxidized phospholipids in infectious diseases [Elektronische Daten] [Ulrich Matt, Omar Sharif, Rui Martins, Sylvia Knapp] Oxidized phospholipids (OxPL) were originally discovered as by-products and mediators of chronic inflammation such as in atherosclerosis. Over the last years, an increasing body of evidence led to the notion that OxPL not only contribute to the pathogenesis of chronic inflammatory processes but in addition play an integral role as modulators of inflammation during acute infections. Thereby, host defense mechanisms involve the generation of oxygen radicalsthat oxidize ubiquitously present phospholipids, which in turn act as danger-associated molecular patterns (DAMPs). These OxPL-derived DAMPs can exhibit both pro- and anti-inflammatory functions that ultimately alter the host response to pathogens. In this review, we summarize the currently available data on the role of OxPL in infectious diseases. Springer Basel, 2014 Oxidized phospholipids nationallicence Infectious diseases nationallicence Danger-associated molecular patterns nationallicence Innate immunity nationallicence ARDS : Acute respiratory distress syndrome nationallicence cAMP : Cyclic adenosine monophosphate nationallicence CD14 : Monocyte differentiation antigen CD14 nationallicence Cdc42 : Cell division control protein 42 homolog nationallicence CRP : C-reactive protein nationallicence DAMP : Danger-associated molecular pattern nationallicence DCs : Dendritic cells nationallicence EP2R : Prostaglandin E2 receptor nationallicence GTP : Guanosine-5′-triphosphate nationallicence HDL : High-density lipoprotein nationallicence LDL : Low-density lipoprotein nationallicence LPS : Lipopolysaccharide nationallicence MARCO : Macrophage receptor with collagenous structure nationallicence NADPH : Nicotinamide adenine dinucleotide phosphate nationallicence NF-κB : Nuclear factor kappa light chain enhancer in B cells nationallicence NLRP3 : NOD-like receptor family, pyrin domain containing 3 nationallicence OxLDL : Oxidized low-density lipoprotein nationallicence OxPAPC : Oxidized 1-palmitoyl-2-arachidonoyl-sn-phosphatidylcholine nationallicence OxPL : Oxidized phospholipids nationallicence p38 : p38 Map kinase nationallicence PAF(R) : Platelet activating factor (receptor) nationallicence PAMP : Pathogen-associated molecular patterns nationallicence Pam3CSK4 : N-Palmitoyl-S-dipalmitoylglyceryl Cys-Ser-(Lys)4 nationallicence PAPC : 1-Palmitoyl-2-arachidonoyl-sn-phosphatidylcholine nationallicence PazPC : 1-Palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine nationallicence PEIPC : 1-Palmitoyl-2-(5,6)-epoxyisoprostane E2-sn-glycero-3-phosphocholine nationallicence PGPC : 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine nationallicence PGE2 : Prostaglandin E2 nationallicence PKA : Protein kinase A nationallicence POVPC : 1-Palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine nationallicence PC : Phosphatidylcholine nationallicence PL : Phospholipids nationallicence Rho : Ras homolog nationallicence Rac : Rho-related C3 botulinum toxin substrate nationallicence ROS : Reactive oxygen species nationallicence SRB-1 : Scavenger receptor class B, member 1 nationallicence TLR : Toll-like receptor nationallicence WAVE1 : Wasp family, verprolin homology domain-containing protein 1 nationallicence Matt Ulrich Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland aut Sharif Omar Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria aut Martins Rui Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria aut Knapp Sylvia Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria aut Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1059-1071 1420-682X 72:6<1059 2015 72 18 https://doi.org/10.1007/s00018-014-1780-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1780-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matt Ulrich Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland aut NATIONALLICENCE 700 1- Sharif Omar Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria aut NATIONALLICENCE 700 1- Martins Rui Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria aut NATIONALLICENCE 700 1- Knapp Sylvia Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/6(2015-03-01), 1059-1071 1420-682X 72:6<1059 2015 72 18