caa a22 4500 606175113 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00018-015-1974-3 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1974-3 GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation [Elektronische Daten] [Sonia Stefanovic, Vincent Christoffels] Heart progenitor cells differentiate into various cell types including pacemaker and working cardiomyocytes. Cell-type specific gene expression is achieved by combinatorial interactions between tissue-specific transcription factors (TFs), co-factors, and chromatin remodelers and DNA binding elements in regulatory regions. Dysfunction of these transcriptional networks may result in congenital heart defects. Functional analysis of the regulatory DNA sequences has contributed substantially to the identification of the transcriptional network components and combinatorial interactions regulating the tissue-specific gene programs. GATA TFs have been identified as central players in these networks. In particular, GATA binding elements have emerged as a platform to recruit broadly active histone modification enzymes and cell-type-specific co-factors to drive cell-type-specific gene programs. Here, we discuss the role of GATA factors in cell fate decisions and differentiation in the developing heart. The Author(s), 2015 Heart development nationallicence Cell fate decisions nationallicence Histone-modifying enzymes nationallicence GATA transcription factor nationallicence Chambers nationallicence Conduction system nationallicence ANF : Atrial natriuretic factor nationallicence AV : Atrioventricular nationallicence BMP : Bone morphogenetic peptide nationallicence BNF : Brain natriuretic factor nationallicence E : Embryonic day nationallicence HAT : Histone acetyl transferase nationallicence HDAC : Histone deacetylase nationallicence TBE : T-box element nationallicence TF : Transcription factor nationallicence Stefanovic Sonia Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands aut Christoffels Vincent Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands aut Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3871-3881 1420-682X 72:20<3871 2015 72 18 https://doi.org/10.1007/s00018-015-1974-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1974-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stefanovic Sonia Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Christoffels Vincent Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3871-3881 1420-682X 72:20<3871 2015 72 18