caa a22 4500 606175121 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00018-015-1975-2 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1975-2 Mesenchymal-epithelial interactions during digestive tract development and epithelial stem cell regeneration [Elektronische Daten] [Ludovic Le Guen, Stéphane Marchal, Sandrine Faure, Pascal de Santa Barbara] The gastrointestinal tract develops from a simple and uniform tube into a complex organ with specific differentiation patterns along the anterior-posterior and dorso-ventral axes of asymmetry. It is derived from all three germ layers and their cross-talk is important for the regulated development of fetal and adult gastrointestinal structures and organs. Signals from the adjacent mesoderm are essential for the morphogenesis of the overlying epithelium. These mesenchymal-epithelial interactions govern the development and regionalization of the different gastrointestinal epithelia and involve most of the key morphogens and signaling pathways, such as the Hedgehog, BMPs, Notch, WNT, HOX, SOX and FOXF cascades. Moreover, the mechanisms underlying mesenchyme differentiation into smooth muscle cells influence the regionalization of the gastrointestinal epithelium through interactions with the enteric nervous system. In the neonatal and adult gastrointestinal tract, mesenchymal-epithelial interactions are essential for the maintenance of the epithelial regionalization and digestive epithelial homeostasis. Disruption of these interactions is also associated with bowel dysfunction potentially leading to epithelial tumor development. In this review, we will discuss various aspects of the mesenchymal-epithelial interactions observed during digestive epithelium development and differentiation and also during epithelial stem cell regeneration. Springer Basel, 2015 Mesenchymal-epithelial interactions nationallicence Anterior-posterior axis nationallicence Gastrointestinal tract nationallicence Epithelial cell nationallicence Smooth muscle cell nationallicence Enteric nervous system nationallicence Myofibroblast nationallicence Stem cell nationallicence Regeneration nationallicence Metaplasia nationallicence Colorectal cancer nationallicence Hedgehog nationallicence Homeotic HOX genes nationallicence BMP pathway nationallicence Notch pathway nationallicence SOX9 nationallicence NKX2.5 nationallicence FOXF nationallicence αSMA : Alpha smooth muscle actin nationallicence AIP : Anterior intestinal portal nationallicence AP : Anterior-posterior nationallicence BMP : Bone morphogenetic protein nationallicence CDX : Caudal type homeobox nationallicence CIP : Caudal intestinal portal nationallicence CRC : Colorectal cancer nationallicence ECM : Extracellular matrix nationallicence ENS : Enteric nervous system nationallicence FGF : Fibroblast growth factor nationallicence GAS1 : Growth arrest specific gene 1 nationallicence GI : Gastrointestinal nationallicence GSEMF : Gastric subepithelial myofibroblast nationallicence IHH : Indian hedgehog nationallicence ISEMF : Intestinal subepithelial myofibroblast nationallicence miR : microRNA nationallicence P-SMAD1 : Phosphorylated SMAD1/5/8 nationallicence SHH : Sonic hedgehog nationallicence SOX9 : Sry-containing box gene 9 nationallicence SM22 : Smooth muscle protein 22 nationallicence SMC : Smooth muscle cell nationallicence TGF-β : Transforming growth factor β nationallicence vENCC : Vagal enteric neural crest cell nationallicence Le Guen Ludovic INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut Marchal Stéphane INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut Faure Sandrine INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut de Santa Barbara Pascal INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3883-3896 1420-682X 72:20<3883 2015 72 18 https://doi.org/10.1007/s00018-015-1975-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1975-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Guen Ludovic INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut NATIONALLICENCE 700 1- Marchal Stéphane INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut NATIONALLICENCE 700 1- Faure Sandrine INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut NATIONALLICENCE 700 1- de Santa Barbara Pascal INSERM U1046, UMR CNRS 9214, Université de Montpellier, 34295, Montpellier, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3883-3896 1420-682X 72:20<3883 2015 72 18