caa a22 4500 606175164 CHVBK 20210128100741.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00018-015-1970-7 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1970-7 Regulation of hepatocyte identity and quiescence [Elektronische Daten] [Carmen Berasain, Matías Avila] The liver is a highly differentiated organ with a central role in metabolism, detoxification and systemic homeostasis. To perform its multiple tasks, liver parenchymal cells, the hepatocytes, express a large complement of enabling genes defining their complex phenotype. This phenotype is progressively acquired during fetal development and needs to be maintained in adulthood to guarantee the individual's survival. Upon injury or loss of functional mass, the liver displays an extraordinary regenerative response, mainly based on the proliferation of hepatocytes which otherwise are long-lived quiescent cells. Increasing observations suggest that loss of hepatocellular differentiation and quiescence underlie liver malfunction in chronic liver disease and pave the way for hepatocellular carcinoma development. Here, we briefly review the essential mechanisms leading to the acquisition of liver maturity. We also identify the key molecular factors involved in the preservation of hepatocellular homeostasis and finally discuss potential strategies to preserve liver identity and function. Springer Basel, 2015 Hepatocyte differentiation nationallicence Hepatocyte proliferation nationallicence Nuclear factors nationallicence Splicing regulator nationallicence Liver function nationallicence Hepatocellular carcinoma nationallicence Cirrhosis nationallicence Berasain Carmen Division of Hepatology, CIMA, University of Navarra, CIBEREHD, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Avda. Pio XII, n55, 31008, Pamplona, Spain aut Avila Matías Division of Hepatology, CIMA, University of Navarra, CIBEREHD, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Avda. Pio XII, n55, 31008, Pamplona, Spain aut Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3831-3851 1420-682X 72:20<3831 2015 72 18 https://doi.org/10.1007/s00018-015-1970-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1970-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berasain Carmen Division of Hepatology, CIMA, University of Navarra, CIBEREHD, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Avda. Pio XII, n55, 31008, Pamplona, Spain aut NATIONALLICENCE 700 1- Avila Matías Division of Hepatology, CIMA, University of Navarra, CIBEREHD, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Avda. Pio XII, n55, 31008, Pamplona, Spain aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3831-3851 1420-682X 72:20<3831 2015 72 18