caa a22 4500 606175199 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00018-015-1981-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1981-4 Oestrogen action and male fertility: experimental and clinical findings [Elektronische Daten] [Xiangdong Li, Haiwen Li, Lina Jia, Xiru Li, Nafis Rahman] A proper balance between androgen and oestrogen is fundamental for normal male reproductive development and function in both animals and humans. This balance is governed by the cytochrome P450 aromatase, which is expressed also under spatio-temporal control. Oestrogen receptors ERα and/or ERβ, together with the membrane-associated G-protein-coupled functional ER (GPER), mediate the effects of oestrogen in the testis. Oestrogen action in male reproduction is more complex than previously predicted. The androgen/oestrogen balance and its regulation in the masculinisation programming window (MPW) during foetal life is the most critical period for the development of the male reproductive system. If this balance is impaired during the MPW, the male reproductive system may be negatively affected. Recent data from genetically modified mice and human infertile patients have shown that oestrogens may promote the engulfment of live Leydig cells by macrophages leading to male infertility. We also discuss recent data on environmental oestrogen exposure in men and rodents, where a rodent-human distinction is crucial and analyse some aspects of male fertility potentially related to impaired oestrogen/androgen balance. Springer Basel, 2015 Oestrogen nationallicence Oestrogen receptor nationallicence Male fertility nationallicence Li Xiangdong State Key Laboratory of the Agro-Biotechnology, Faculty of Biological Sciences, China Agricultural University, Beijing, China aut Li Haiwen Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA aut Jia Lina State Key Laboratory of the Agro-Biotechnology, Faculty of Biological Sciences, China Agricultural University, Beijing, China aut Li Xiru Department of General Surgery, The 301th Hospital of PLA, Beijing, China aut Rahman Nafis Department of Physiology, Institute F Biomedicine, University of Turku, Turku, Finland aut Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3915-3930 1420-682X 72:20<3915 2015 72 18 https://doi.org/10.1007/s00018-015-1981-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1981-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Xiangdong State Key Laboratory of the Agro-Biotechnology, Faculty of Biological Sciences, China Agricultural University, Beijing, China aut NATIONALLICENCE 700 1- Li Haiwen Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA aut NATIONALLICENCE 700 1- Jia Lina State Key Laboratory of the Agro-Biotechnology, Faculty of Biological Sciences, China Agricultural University, Beijing, China aut NATIONALLICENCE 700 1- Li Xiru Department of General Surgery, The 301th Hospital of PLA, Beijing, China aut NATIONALLICENCE 700 1- Rahman Nafis Department of Physiology, Institute F Biomedicine, University of Turku, Turku, Finland aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/20(2015-10-01), 3915-3930 1420-682X 72:20<3915 2015 72 18