caa a22 4500 606175253 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-014-1832-8 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1832-8 c-kit+ cells: the tell-tale heart of cardiac regeneration? [Elektronische Daten] [Patrizia Nigro, Gianluca Perrucci, Aoife Gowran, Marco Zanobini, Maurizio Capogrossi, Giulio Pompilio] Cardiovascular disease is the leading cause of morbidity and mortality in the developed world. Although ongoing therapeutic strategies ameliorate symptoms and prolong life for patients with cardiovascular diseases, they do not solve the critical issue related to the loss of cardiac tissue. Accordingly, stem/progenitor cell therapy has emerged as a paramount approach for cardiac repair and regeneration. In this regard, c-kit+ cells have animated much interest and controversy. These cells are self-renewing, clonogenic, and multipotent and display a noteworthy potential to differentiate into all cardiovascular lineages. However, their functional contribution to cardiomyocyte turnover is one of the centrally debated issues concerning their regenerative potential. Regardless, plentiful preclinical and clinical studies have been conducted which provide evidence for the capacity of c-kit+ cells to improve cardiac function. The purpose of this review is to give a comprehensive, impartial, critical description and evaluation of the literature on c-kit+ cells from bench to bedside in order to address their true potential, benefits and controversies. Springer Basel, 2015 Cardiovascular disease nationallicence c-kit+ cells nationallicence Myocardial regeneration nationallicence Cell therapy nationallicence Nigro Patrizia Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut Perrucci Gianluca Department of Clinical and Community Sciences, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy aut Gowran Aoife Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut Zanobini Marco Department of Cardiovascular Surgery, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut Capogrossi Maurizio Laboratory of Vascular Pathology, Istituto Dermopatico dell'Immacolata-IRCCS, Via Monti di Creta 104, 00167, Rome, Italy aut Pompilio Giulio Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1725-1740 1420-682X 72:9<1725 2015 72 18 https://doi.org/10.1007/s00018-014-1832-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1832-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nigro Patrizia Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Perrucci Gianluca Department of Clinical and Community Sciences, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy aut NATIONALLICENCE 700 1- Gowran Aoife Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Zanobini Marco Department of Cardiovascular Surgery, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Capogrossi Maurizio Laboratory of Vascular Pathology, Istituto Dermopatico dell'Immacolata-IRCCS, Via Monti di Creta 104, 00167, Rome, Italy aut NATIONALLICENCE 700 1- Pompilio Giulio Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138, Milan, Italy aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1725-1740 1420-682X 72:9<1725 2015 72 18