caa a22 4500 60617527X CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-015-1833-2 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1833-2 Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network [Elektronische Daten] [Guanyi Huang, Shoudong Ye, Xingliang Zhou, Dahai Liu, Qi-Long Ying] Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the capacity to generate any type of cell in the body, and therefore not only hold great promise for tissue repair and regeneration, but also provide a powerful tool for modeling human disease and understanding biological development. In order to fulfill the full potential of ESCs, it is critical to understand how ESC fate, whether to self-renew or to differentiate into specialized cells, is regulated. On the molecular level, ESC fate is controlled by the intracellular transcriptional regulatory networks that respond to various extrinsic signaling stimuli. In this review, we discuss and compare important signaling pathways in the self-renewal and differentiation of mouse, rat, and human ESCs with an emphasis on how these pathways integrate into ESC-specific transcription circuitries. This will be beneficial for understanding the common and conserved mechanisms that govern self-renewal, and for developing novel culture conditions that support ESC derivation and maintenance. Springer Basel, 2015 Embryonic stem cells nationallicence Stem cell self-renewal nationallicence Pluripotency nationallicence LIF/Stat3 signaling pathway nationallicence Wnt/β-catenin signaling pathway nationallicence Huang Guanyi Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, 230601, Hefei, PR China aut Ye Shoudong Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, 230601, Hefei, PR China aut Zhou Xingliang Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut Liu Dahai Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, 230601, Hefei, PR China aut Ying Qi-Long Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1741-1757 1420-682X 72:9<1741 2015 72 18 https://doi.org/10.1007/s00018-015-1833-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1833-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Guanyi Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, 230601, Hefei, PR China aut NATIONALLICENCE 700 1- Ye Shoudong Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, 230601, Hefei, PR China aut NATIONALLICENCE 700 1- Zhou Xingliang Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Liu Dahai Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, 230601, Hefei, PR China aut NATIONALLICENCE 700 1- Ying Qi-Long Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1741-1757 1420-682X 72:9<1741 2015 72 18