caa a22 4500 60617530X CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-014-1830-x doi (NATIONALLICENCE)springer-10.1007/s00018-014-1830-x CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target [Elektronische Daten] [Aparecida de Lourdes Perim, Marla Amarante, Roberta Guembarovski, Carlos de Oliveira, Maria Watanabe] Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy, accounting for approximately 80% of leukemia in the pediatric group, and its etiology is unknown. This neoplasia is characterized by male predominance, high-risk features and poor outcome, mainly in recurrence patients and adults. In recent years, advances in the success of childhood ALL treatment were verified, and the rate of cure is over 80% of individuals. However, there is a considerable scope for improving therapeutic outcome in this neoplasia. Improvements in ALL therapy might readily be achieved by developing additional biomarkers that can predict and refine prognosis in patients with ALL. In normal hematopoietic cells, cytokines provide the stimulus for proliferation, survival, self-renewal, differentiation and functional activation. Abnormalities of cytokines are characteristic in all forms of leukemia, including ALL. The stromal cell-derived factor-1 (SDF-1 or CXCL12) is a member of the CXC chemokine family that binds to CXC chemokine receptor 4 (CXCR4). The CXCL12/CXCR4 axis appears to play a role in dissemination of solid tumors and hematopoietic diseases. Understanding the mechanisms by which ALL cells are disseminated will provide additional information to expand therapeutic approach. Therefore, this review summarizes information relating to ALL cell biology, focusing specifically in a cytokine receptor important axis, CXCL12/CXCR4, that may have implications for novel treatment strategies to improve life expectancy of patients with this neoplasia. Springer Basel, 2015 Acute lymphoblastic leukemia nationallicence CXCL12 nationallicence CXCR4 nationallicence Therapeutic target nationallicence de Lourdes Perim Aparecida Laboratory of Hematology, Department of Pathology, Clinical and Toxicological Analysis, Health Sciences Center, State University of Londrina, Av. Robert Koch, 60, Vila Operária, 86038-440, Londrina, PR, Brazil aut Amarante Marla Laboratory of Hematology, Department of Pathology, Clinical and Toxicological Analysis, Health Sciences Center, State University of Londrina, Av. Robert Koch, 60, Vila Operária, 86038-440, Londrina, PR, Brazil aut Guembarovski Roberta Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário-Rod. Celso Garcia Cid (PR 445) Km 380, 86051-970, Londrina, PR, Brazil aut de Oliveira Carlos Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário-Rod. Celso Garcia Cid (PR 445) Km 380, 86051-970, Londrina, PR, Brazil aut Watanabe Maria Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário-Rod. Celso Garcia Cid (PR 445) Km 380, 86051-970, Londrina, PR, Brazil aut Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1715-1723 1420-682X 72:9<1715 2015 72 18 https://doi.org/10.1007/s00018-014-1830-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1830-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Lourdes Perim Aparecida Laboratory of Hematology, Department of Pathology, Clinical and Toxicological Analysis, Health Sciences Center, State University of Londrina, Av. Robert Koch, 60, Vila Operária, 86038-440, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- Amarante Marla Laboratory of Hematology, Department of Pathology, Clinical and Toxicological Analysis, Health Sciences Center, State University of Londrina, Av. Robert Koch, 60, Vila Operária, 86038-440, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- Guembarovski Roberta Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário-Rod. Celso Garcia Cid (PR 445) Km 380, 86051-970, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- de Oliveira Carlos Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário-Rod. Celso Garcia Cid (PR 445) Km 380, 86051-970, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- Watanabe Maria Laboratory of Study and Application of DNA Polymorphisms, Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário-Rod. Celso Garcia Cid (PR 445) Km 380, 86051-970, Londrina, PR, Brazil aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1715-1723 1420-682X 72:9<1715 2015 72 18