caa a22 4500 606175318 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-014-1818-6 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1818-6 A nuclear odyssey: fibroblast growth factor-2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system [Elektronische Daten] [Benjamin Förthmann, Claudia Grothe, Peter Claus] Nuclear localization of classical growth factors is a well-known phenomenon but still remains a molecular and cellular conundrum. Fibroblast growth factor-2 (FGF-2) is an excellent example of a protein which functions as an extracellular molecule involved in canonical receptor tyrosine kinase signaling as well as displaying intracellular functions. Paracrine and nuclear functions are two important sides of the same protein. FGF-2 is expressed in isoforms with different molecular weights from one mRNA species. In rodents, all of these isoforms become imported to the nucleus. In this review, we discuss structural and functional aspects of FGF-2 isoforms in the nervous system. The nuclear odyssey of FGF-2 is reflected by nuclear dynamics, localization to nuclear bodies such as nucleoli, binding to chromatin and engagement in various protein interactions. Recently discovered molecular partnerships of the isoforms shed light on their nuclear functions, thereby greatly extending our knowledge of the multifaceted functions of FGF-2. Springer Basel, 2014 FGF signaling nationallicence Isoforms nationallicence Neurotrophic factor nationallicence Nuclear protein nationallicence SMN nationallicence Chromatin nationallicence Splicing nationallicence Spinal muscular atrophy (SMA) nationallicence Parkinson´s disease nationallicence CB : Cajal body nationallicence SMN : Survival of motoneuron protein nationallicence SMA : Spinal muscular atrophy nationallicence FGF : Fibroblast growth factor nationallicence snRNP : Small nuclear ribonucleoprotein particle nationallicence Förthmann Benjamin Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Grothe Claudia Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Claus Peter Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1651-1662 1420-682X 72:9<1651 2015 72 18 https://doi.org/10.1007/s00018-014-1818-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1818-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Förthmann Benjamin Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Grothe Claudia Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 700 1- Claus Peter Department of Neuroanatomy, Institute of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Str.1, 30625, Hannover, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1651-1662 1420-682X 72:9<1651 2015 72 18