caa a22 4500 606175326 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-014-1805-y doi (NATIONALLICENCE)springer-10.1007/s00018-014-1805-y Nuclear bile acid signaling through the farnesoid X receptor [Elektronische Daten] [Claire Mazuy, Audrey Helleboid, Bart Staels, Philippe Lefebvre] Bile acids (BAs) are amphipathic molecules produced from cholesterol by the liver. Expelled from the gallbladder upon meal ingestion, BAs serve as fat solubilizers in the intestine. BAs are reabsorbed in the ileum and return via the portal vein to the liver where, together with nutrients, they provide signals to coordinate metabolic responses. BAs act on energy and metabolic homeostasis through the activation of membrane and nuclear receptors, among which the nuclear receptor farnesoid X receptor (FXR) is an important regulator of several metabolic pathways. Highly expressed in the liver and the small intestine, FXR contributes to BA effects on metabolism, inflammation and cell cycle control. The pharmacological modulation of its activity has emerged as a potential therapeutic strategy for liver and metabolic diseases. This review highlights recent advances regarding the mechanisms by which the BA sensor FXR contributes to global signaling effects of BAs, and how FXR activity may be regulated by nutrient-sensitive signaling pathways. Springer Basel, 2014 FXR nationallicence Nuclear receptor nationallicence Bile acids nationallicence Homeostasis nationallicence Metabolism nationallicence Mazuy Claire European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut Helleboid Audrey European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut Staels Bart European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut Lefebvre Philippe European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1631-1650 1420-682X 72:9<1631 2015 72 18 https://doi.org/10.1007/s00018-014-1805-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1805-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mazuy Claire European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut NATIONALLICENCE 700 1- Helleboid Audrey European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut NATIONALLICENCE 700 1- Staels Bart European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut NATIONALLICENCE 700 1- Lefebvre Philippe European Genomic Institute for Diabetes (EGID), 59000, Lille, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1631-1650 1420-682X 72:9<1631 2015 72 18