caa a22 4500 606175342 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00018-015-1834-1 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1834-1 Metabolic restructuring and cell fate conversion [Elektronische Daten] [Alessandro Prigione, María Ruiz-Pérez, Raul Bukowiecki, James Adjaye] Accumulating evidence implicates mitochondrial and metabolic pathways in the establishment of pluripotency, as well as in the control of proliferation and differentiation programs. From classic studies in mouse embryos to the latest findings in adult stem cells, human embryonic and induced pluripotent stem cells, an increasing number of evidence suggests that mitochondrial and metabolic-related processes might intertwine with signaling networks and epigenetic rewiring, thereby modulating cell fate decisions. This review summarizes the progresses in this exciting field of research. Dissecting these complex mitochondrial and metabolic mechanisms may lead to a more comprehensive understanding of stemness biology and to potential improvements in stem cell applications for biomedicine, cell therapy, and disease modeling. Springer Basel, 2015 iPSCs nationallicence Mitochondria nationallicence Metabolism nationallicence Stem cells nationallicence Reprogramming nationallicence Pluripotency nationallicence Prigione Alessandro Max Delbrueck Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany aut Ruiz-Pérez María Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, 29071, Málaga, Spain aut Bukowiecki Raul Max Delbrueck Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany aut Adjaye James Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Duesseldorf, Germany aut Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1759-1777 1420-682X 72:9<1759 2015 72 18 https://doi.org/10.1007/s00018-015-1834-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1834-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prigione Alessandro Max Delbrueck Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Ruiz-Pérez María Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, 29071, Málaga, Spain aut NATIONALLICENCE 700 1- Bukowiecki Raul Max Delbrueck Center for Molecular Medicine (MDC), Robert-Roessle-Str. 10, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Adjaye James Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University, Duesseldorf, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/9(2015-05-01), 1759-1777 1420-682X 72:9<1759 2015 72 18