caa a22 4500 606175350 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1801-2 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1801-2 Marie Pierre INSERM UMR-1132, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France aut Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies [Elektronische Daten] [Pierre Marie] Several metabolic, genetic and oncogenic bone diseases are characterized by defective or excessive bone formation. These abnormalities are caused by dysfunctions in the commitment, differentiation or survival of cells of the osteoblast lineage. During the recent years, significant advances have been made in our understanding of the cellular and molecular mechanisms underlying the osteoblast dysfunctions in osteoporosis, skeletal dysplasias and primary bone tumors. This led to suggest novel therapeutic approaches to correct these abnormalities such as the modulation of WNT signaling, the pharmacological modulation of proteasome-mediated protein degradation, the induction of osteoprogenitor cell differentiation, the repression of cancer cell proliferation and the manipulation of epigenetic mechanisms. This article reviews our current understanding of the major cellular and molecular mechanisms inducing osteoblastic cell abnormalities in age-related bone loss, genetic skeletal dysplasias and primary bone tumors, and discusses emerging therapeutic strategies to counteract the osteoblast abnormalities in these disorders of bone formation. Springer Basel, 2014 Bone formation nationallicence Osteoporosis nationallicence Skeletal dysplasias nationallicence Genetic mutations nationallicence Osteosarcoma nationallicence Treatments nationallicence Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1347-1361 1420-682X 72:7<1347 2015 72 18 https://doi.org/10.1007/s00018-014-1801-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1801-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Marie Pierre INSERM UMR-1132, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1347-1361 1420-682X 72:7<1347 2015 72 18