caa a22 4500 606175385 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1797-7 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1797-7 Are stem cells a potential therapeutic tool in coeliac disease? [Elektronische Daten] [Rachele Ciccocioppo, Giuseppina Cangemi, Emanuela Roselli, Peter Kruzliak] Despite the growing understanding of its pathogenesis, the treatment of coeliac disease is still based on a lifelong gluten-free diet that, although efficacious, is troublesome for affected patients, and a definitive cure is still an unmet need. In this regard, the development of new chemical- and biological-derived agents has often resulted in unsatisfactory effects when tested in vivo, probably because of their ability to target only a single pathway, whilst the immunological cascade responsible for tissue injury is complex and redundant. The advent of cellular therapies, mainly based on the use of stem cells, is an emerging area of interest since it has the advantage of a multi-target strategy. Both haematopoietic and mesenchymal stem cells have been employed in the treatment of refractory patients suffering from autoimmune diseases, with promising results. However, the lack of immunogenicity makes mesenchymal stem cells more suitable than their haematopoietic counterpart, since their transplantation may be performed in the absence of a myeloablative conditioning regimen. In addition, mesenchymal stem cells have been shown to harbour strong modulatory effects on almost all cells involved in immune response, together with a potent regenerative action. It is therefore conceivable that over the next few years their therapeutic use will increase as their biological interactions with injured tissues become clearer. Springer Basel, 2014 Coeliac disease nationallicence Haematopoietic stem cells nationallicence Mesenchymal stem cells nationallicence Therapy nationallicence CD : Coeliac disease nationallicence EATL : Enteropathy-associated T cell lymphoma nationallicence Fox : Transcription factor Forkhead box nationallicence GFD : Gluten-free diet nationallicence HSC : Haematopoietic stem cell nationallicence HGF : Hepatocyte growth factor nationallicence HLA : Histocompatibility locus antigen nationallicence IDO : Indoleamine 2,3-dioxygenase nationallicence IFN : Interferon nationallicence IL : Interleukin nationallicence IEL : Intraepithelial lymphocyte nationallicence JAK : Janus kinase nationallicence MSC : Mesenchymal stem cells nationallicence NO : Nitric oxide nationallicence PGE2 : Prostaglandin E2 nationallicence STAT : Signal transducer and activator of transcription nationallicence TGF : Transforming growth factor nationallicence TNF : Tumour necrosing factor nationallicence VEGF : Vascular endothelial growth factor nationallicence Ciccocioppo Rachele Center for the Study and Cure of Coeliac Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi, 19, 27100, Pavia, Italy aut Cangemi Giuseppina Center for the Study and Cure of Coeliac Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi, 19, 27100, Pavia, Italy aut Roselli Emanuela Center for the Study and Cure of Coeliac Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi, 19, 27100, Pavia, Italy aut Kruzliak Peter International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic aut Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1317-1329 1420-682X 72:7<1317 2015 72 18 https://doi.org/10.1007/s00018-014-1797-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1797-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ciccocioppo Rachele Center for the Study and Cure of Coeliac Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Cangemi Giuseppina Center for the Study and Cure of Coeliac Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Roselli Emanuela Center for the Study and Cure of Coeliac Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Kruzliak Peter International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1317-1329 1420-682X 72:7<1317 2015 72 18