caa a22 4500 606175407 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1794-x doi (NATIONALLICENCE)springer-10.1007/s00018-014-1794-x Signaling pathways in mouse and human trophoblast differentiation: a comparative review [Elektronische Daten] [Francesca Soncin, David Natale, Mana Parast] The mouse is often used as a model for understanding human placentation and offers multiple advantages, including the ability to manipulate gene expression in specific compartments and to derive trophoblast stem cells, which can be maintained or differentiated in vitro. Nevertheless, there are numerous differences between the mouse and human placentas, only the least of which are structural. This review aims to compare mouse and human placentation, with a focus on signaling pathways involved in trophoblast lineage-specific differentiation. Springer Basel, 2014 Placenta nationallicence Trophoblast stem cells nationallicence Cytotrophoblast nationallicence Syncytiotrophoblast nationallicence Extravillous trophoblast nationallicence Trophoblast giant cells nationallicence Labyrinth nationallicence Chorionic villi nationallicence CTB : Cytotrophoblast nationallicence EGF : Epidermal growth factor nationallicence EPC : Ectoplacental cone nationallicence EVT : Extravillous trophoblast nationallicence FAK : Focal adhesion kinase nationallicence FGF : Fibroblast growth factor nationallicence HGF : Hepatocyte growth factor nationallicence HIF : Hypoxia-inducible factor nationallicence ICM : Inner cell mass nationallicence MEF : Mouse embryonic fibroblast nationallicence PI3K : Phosphoinositide 3-kinase nationallicence PKA : Protein kinase A nationallicence STB : Syncytiotrophoblast nationallicence TE : Trophectoderm nationallicence TGC : Trophoblast giant cell nationallicence TS : Trophoblast stem (cells) nationallicence Soncin Francesca Department of Pathology, Sanford Consortium for Regenerative Medicine, University of California San Diego, 9500 Gilman Drive, MC 0695, 92093, La Jolla, CA, USA aut Natale David Department of Reproductive Medicine, University of California San Diego, 2A03 Leichtag Biomedical Research Building, 9500 Gilman Drive, MC 0674, 92093, La Jolla, CA, USA aut Parast Mana Department of Pathology, Sanford Consortium for Regenerative Medicine, University of California San Diego, 9500 Gilman Drive, MC 0695, 92093, La Jolla, CA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1291-1302 1420-682X 72:7<1291 2015 72 18 https://doi.org/10.1007/s00018-014-1794-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1794-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Soncin Francesca Department of Pathology, Sanford Consortium for Regenerative Medicine, University of California San Diego, 9500 Gilman Drive, MC 0695, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Natale David Department of Reproductive Medicine, University of California San Diego, 2A03 Leichtag Biomedical Research Building, 9500 Gilman Drive, MC 0674, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Parast Mana Department of Pathology, Sanford Consortium for Regenerative Medicine, University of California San Diego, 9500 Gilman Drive, MC 0695, 92093, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1291-1302 1420-682X 72:7<1291 2015 72 18