caa a22 4500 606175423 CHVBK 20210128100742.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1791-0 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1791-0 MITF in melanoma: mechanisms behind its expression and activity [Elektronische Daten] [Mariusz Hartman, Malgorzata Czyz] MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-specific transcription factor whose role is profoundly extended in malignant melanoma. Over the last few years, the function of MITF has been tightly connected to plasticity of melanoma cells. MITF participates in executing diverse melanoma phenotypes defined by distinct gene expression profiles. Mutation-dependent alterations in MITF expression and activity have been found in a relatively small subset of melanomas. MITF activity is rather modulated by its upstream activators and suppressors operating on transcriptional, post-transcriptional and post-translational levels. These regulatory mechanisms also include epigenetic and microenvironmental signals. Several transcription factors and signaling pathways involved in the regulation of MITF expression and/or activity such as the Wnt/β-catenin pathway are broadly utilized by various types of tumors, whereas others, e.g., BRAFV600E/ERK1/2 are more specific for melanoma. Furthermore, the MITF activity can be affected by the availability of transcriptional co-partners that are often redirected by MITF from their own canonical signaling pathways. In this review, we discuss the complexity of a multilevel regulation of MITF expression and activity that underlies distinct context-related phenotypes of melanoma and might explain diverse responses of melanoma patients to currently used therapeutics. The Author(s), 2014 BRAFV600E nationallicence Melanoma cancer plasticity nationallicence Gene regulation nationallicence MicroRNA nationallicence MITF nationallicence Oncogene nationallicence Transcription factor nationallicence Hartman Mariusz Department of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland aut Czyz Malgorzata Department of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland aut Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1249-1260 1420-682X 72:7<1249 2015 72 18 https://doi.org/10.1007/s00018-014-1791-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1791-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hartman Mariusz Department of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland aut NATIONALLICENCE 700 1- Czyz Malgorzata Department of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1249-1260 1420-682X 72:7<1249 2015 72 18