caa a22 4500 606175458 CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1796-8 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1796-8 Physical and mechanical regulation of macrophage phenotype and function [Elektronische Daten] [Frances McWhorter, Chase Davis, Wendy Liu] Macrophages are tissue-resident immune cells that play a critical role in maintaining homeostasis and fighting infection. In addition, these cells are involved in the progression of many pathologies including cancer and atherosclerosis. In response to a variety of microenvironmental stimuli, macrophages can be polarized to achieve a spectrum of functional phenotypes. This review will discuss some emerging evidence in support of macrophage phenotypic regulation by physical and mechanical cues. As alterations in the physical microenvironment often underlie pathophysiological states, an understanding of their effects on macrophage phenotype and function may help provide mechanistic insights into disease pathogenesis. Springer Basel, 2014 Macrophages nationallicence Phenotype nationallicence Polarization nationallicence Microenvironment nationallicence Mechanotransduction nationallicence McWhorter Frances Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, 92697, Irvine, CA, USA aut Davis Chase Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, 92697, Irvine, CA, USA aut Liu Wendy Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, 92697, Irvine, CA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1303-1316 1420-682X 72:7<1303 2015 72 18 https://doi.org/10.1007/s00018-014-1796-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1796-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McWhorter Frances Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Davis Chase Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Liu Wendy Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, 92697, Irvine, CA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1303-1316 1420-682X 72:7<1303 2015 72 18