caa a22 4500 606175466 CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00018-014-1799-5 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1799-5 Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense [Elektronische Daten] [Kayluz Boligan, Circe Mesa, Luis Fernandez, Stephan von Gunten] Aberrant glycosylation is a key feature of malignant transformation and reflects epigenetic and genetic anomalies among the multitude of molecules involved in glycan biosynthesis. Although glycan biosynthesis is not template bound, altered tumor glycosylation is not random, but associated with common glycosylation patterns. Evidence suggests that acquisition of distinct glycosylation patterns evolves from a ‘microevolutionary' process conferring advantages in terms of tumor growth, tumor dissemination, and immune escape. Such glycosylation modifications also involve xeno- and hypersialylation. Xeno-autoantigens such as Neu5Gc-gangliosides provide potential targets for immunotherapy. Hypersialylation may display ‘enhanced self' to escape immunosurveillance and involves several not mutually exclusive inhibitory pathways that all rely on protein-glycan interactions. A better understanding of tumor ‘glycan codes' as deciphered by lectins, such as siglecs, selectins, C-type lectins and galectins, may lead to novel treatment strategies, not only in cancer, but also in autoimmune disease or transplantation. Springer Basel, 2014 Xeno-autosialylation nationallicence Cancer glycosylation nationallicence Cancer immunoediting nationallicence Sialoglycans nationallicence Altered branching nationallicence Tumor immunosuppression nationallicence C2GnT : Core 2 β1,6-N-acetylglucosaminyltransferase nationallicence CEACAM-1 : CEA-related cell adhesion molecule-1 nationallicence CLR : C-type lectin receptors nationallicence CRD : Carbohydrate-recognition domains nationallicence DTDST : Diastrophic dysplasia sulfate transporter nationallicence FUT : Fucosyltransferase nationallicence ITIM : Immunoreceptor tyrosine-based inhibition motif nationallicence LOH : Loss of heterozygosity nationallicence MGAT3 : Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase nationallicence MGAT5 : Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase nationallicence MICA : MHC class I-related chain A nationallicence NGcGM3 : N-Glycolyl GM3 ganglioside nationallicence NAcGM3 : N-Acetyl GM3 ganglioside nationallicence NSCLC : Non-small cell lung cancer nationallicence ppGalNAcT : Polypeptide N-acetylgalactosyl transferase nationallicence PSGL-1 : P-selectin glycoprotein ligand-1 nationallicence SAMPs : Self-associated molecular patterns nationallicence Siglec : Sialic acid-binding immunoglobulin-like lectin nationallicence sT : Sialyl-T antigen nationallicence ST6Gal 1 : Beta-galactoside α-2,6-sialyltransferase 1 nationallicence sTn : Sialyl-Tn antigen nationallicence T : Thomsen-Friedenreich nationallicence TACA : Tumor-associated carbohydrate antigen nationallicence VSSP : Very small-sized proteoliposomes nationallicence Boligan Kayluz Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, 3010, Bern, Switzerland aut Mesa Circe Immunobiology Division, Center of Molecular Immunology, 216 St and 15th Ave., Atabey, Playa, P.O. Box 16040, 11600, Havana, Cuba aut Fernandez Luis Innovation Division, Center of Molecular Immunology, 216 St and 15th Ave., Atabey, Playa, P.O. Box 16040, 11600, Havana, Cuba aut von Gunten Stephan Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, 3010, Bern, Switzerland aut Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1231-1248 1420-682X 72:7<1231 2015 72 18 https://doi.org/10.1007/s00018-014-1799-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1799-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boligan Kayluz Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, 3010, Bern, Switzerland aut NATIONALLICENCE 700 1- Mesa Circe Immunobiology Division, Center of Molecular Immunology, 216 St and 15th Ave., Atabey, Playa, P.O. Box 16040, 11600, Havana, Cuba aut NATIONALLICENCE 700 1- Fernandez Luis Innovation Division, Center of Molecular Immunology, 216 St and 15th Ave., Atabey, Playa, P.O. Box 16040, 11600, Havana, Cuba aut NATIONALLICENCE 700 1- von Gunten Stephan Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, 3010, Bern, Switzerland aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/7(2015-04-01), 1231-1248 1420-682X 72:7<1231 2015 72 18