caa a22 4500 606175520 CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1862-x doi (NATIONALLICENCE)springer-10.1007/s00018-015-1862-x Role of Rab GTPases and their interacting proteins in mediating metabolic signalling and regulation [Elektronische Daten] [Christelle Chua, Bor Tang] The vesicular transport pathways, which shuttle materials to and from the cell surface and within the cell, and the metabolic (growth factor and nutrient) signalling pathways, which integrate a variety of extracellular and intracellular signals to mediate growth, proliferation or survival, are both important for cellular physiology. There is evidence to suggest that the transport and metabolic signalling pathways intersect—vesicular transport can affect the regulation of metabolic signals and vice versa. The Rab family GTPases regulate the specificity of vesicular transport steps in the cell. Together with their interacting proteins, Rabs would likely constitute the points of intersection between vesicular transport and metabolic signalling pathways. Examples of these points would include growth factor signalling, glucose and lipid metabolism, as well as autophagy. Many of these processes involve mechanistic/mammalian target of rapamycin (mTOR) complex 1 (mTORC1) in downstream cascades, or are regulated by TORC signalling. A general functionality of the vesicular transport processes controlled by the Rabs is also important for spatial and temporal regulation of the transmission of metabolic signals between the cell surface and the nucleus. In other cases, specific Rabs and their interacting proteins are known to function in recruiting metabolism-related proteins to target membranes, or may compete with other factors in the TORC signalling pathway as a means of metabolic regulation. We review and discuss herein examples of how Rabs and their interacting proteins can mediate metabolic signalling and regulation in cells. Springer Basel, 2015 Rab GTPases nationallicence Growth factor signalling nationallicence Metabolism nationallicence Autophagy nationallicence TORC nationallicence Vesicular trafficking nationallicence Chua Christelle Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, 8 Medical Drive, 117597, Singapore, Singapore aut Tang Bor Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, 8 Medical Drive, 117597, Singapore, Singapore aut Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2289-2304 1420-682X 72:12<2289 2015 72 18 https://doi.org/10.1007/s00018-015-1862-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1862-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chua Christelle Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, 8 Medical Drive, 117597, Singapore, Singapore aut NATIONALLICENCE 700 1- Tang Bor Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, 8 Medical Drive, 117597, Singapore, Singapore aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2289-2304 1420-682X 72:12<2289 2015 72 18