caa a22 4500 606175547 CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1872-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1872-8 Comparative analyses of lysophosphatidic acid receptor-mediated signaling [Elektronische Daten] [Nobuyuki Fukushima, Shoichi Ishii, Toshifumi Tsujiuchi, Nao Kagawa, Kazutaka Katoh] Lysophosphatidic acid (LPA) is a bioactive lipid mediator that activates G protein-coupled LPA receptors to exert fundamental cellular functions. Six LPA receptor genes have been identified in vertebrates and are classified into two subfamilies, the endothelial differentiation genes (edg) and the non-edg family. Studies using genetically engineered mice, frogs, and zebrafish have demonstrated that LPA receptor-mediated signaling has biological, developmental, and pathophysiological functions. Computational analyses have also identified several amino acids (aa) critical for LPA recognition by human LPA receptors. This review focuses on the evolutionary aspects of LPA receptor-mediated signaling by comparing the aa sequences of vertebrate LPA receptors and LPA-producing enzymes; it also summarizes the LPA receptor-dependent effects commonly observed in mouse, frog, and fish. Springer Basel, 2015 Phylogenetic tree nationallicence Evolution nationallicence Lpar nationallicence ATX nationallicence LIPH nationallicence LIPI nationallicence Lipase nationallicence Fukushima Nobuyuki Division of Molecular Neurobiology, Department of Life Science, Kinki University, 577-8502, Higashiosaka, Japan aut Ishii Shoichi Division of Molecular Neurobiology, Department of Life Science, Kinki University, 577-8502, Higashiosaka, Japan aut Tsujiuchi Toshifumi Division of Cancer Biology and Bioinformatics, Department of Life Science, Kinki University, Higashiosaka, Japan aut Kagawa Nao Division of Animal Genetics, Department of Life Science, Kinki University, Higashiosaka, Japan aut Katoh Kazutaka Immunology Frontier Research Center, Osaka University, 565-0871, Suita, Osaka, Japan aut Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2377-2394 1420-682X 72:12<2377 2015 72 18 https://doi.org/10.1007/s00018-015-1872-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1872-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fukushima Nobuyuki Division of Molecular Neurobiology, Department of Life Science, Kinki University, 577-8502, Higashiosaka, Japan aut NATIONALLICENCE 700 1- Ishii Shoichi Division of Molecular Neurobiology, Department of Life Science, Kinki University, 577-8502, Higashiosaka, Japan aut NATIONALLICENCE 700 1- Tsujiuchi Toshifumi Division of Cancer Biology and Bioinformatics, Department of Life Science, Kinki University, Higashiosaka, Japan aut NATIONALLICENCE 700 1- Kagawa Nao Division of Animal Genetics, Department of Life Science, Kinki University, Higashiosaka, Japan aut NATIONALLICENCE 700 1- Katoh Kazutaka Immunology Frontier Research Center, Osaka University, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2377-2394 1420-682X 72:12<2377 2015 72 18