caa a22 4500 606175571 CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1871-9 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1871-9 Eukaryotic enhancers: common features, regulation, and participation in diseases [Elektronische Daten] [Maksim Erokhin, Yegor Vassetzky, Pavel Georgiev, Darya Chetverina] Enhancers are positive DNA regulatory sequences controlling temporal and tissue-specific gene expression. These elements act independently of their orientation and distance relative to the promoters of target genes. Enhancers act through a variety of transcription factors that ensure their correct match with target promoters and consequent gene activation. There is a growing body of evidence on association of enhancers with transcription factors, co-activators, histone chromatin marks, and lncRNAs. Alterations in enhancers lead to misregulation of gene expression, causing a number of human diseases. In this review, we focus on the common characteristics of enhancers required for transcription stimulation. Springer Basel, 2015 Chromatin loop nationallicence Gene regulation nationallicence Epigenetics nationallicence Transcription nationallicence Regulatory elements nationallicence Erokhin Maksim Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334, Moscow, Russia aut Vassetzky Yegor LIA 1066, Laboratoire Franco-Russe de recherche en oncologie, 119334, Moscow, Russia aut Georgiev Pavel Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334, Moscow, Russia aut Chetverina Darya Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334, Moscow, Russia aut Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2361-2375 1420-682X 72:12<2361 2015 72 18 https://doi.org/10.1007/s00018-015-1871-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1871-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Erokhin Maksim Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334, Moscow, Russia aut NATIONALLICENCE 700 1- Vassetzky Yegor LIA 1066, Laboratoire Franco-Russe de recherche en oncologie, 119334, Moscow, Russia aut NATIONALLICENCE 700 1- Georgiev Pavel Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334, Moscow, Russia aut NATIONALLICENCE 700 1- Chetverina Darya Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334, Moscow, Russia aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2361-2375 1420-682X 72:12<2361 2015 72 18