caa a22 4500 60617558X CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1870-x doi (NATIONALLICENCE)springer-10.1007/s00018-015-1870-x The role of FcεRI expressed in dendritic cells and monocytes [Elektronische Daten] [Jeoung-Sook Shin, Alexandra Greer] Early studies regarding the function of FcεRI in dendritic cells (DCs) and monocytes have focused on its role in mediating inflammatory signaling and enhancing T cell immunity. It has been the case in part because FcεRI is the major receptor that mediates allergic inflammatory signaling in mast cells and basophils and because DCs and monocytes are antigen presenting cells capable of activating naïve and/or effector T cells. These studies have led to the general belief that FcεRI-mediated DC signaling and antigen presentation promote development and activation of Th2 cells and contribute to allergic inflammatory diseases. However, this belief has long suffered from a lack of evidence. Recently, studies have emerged that provide evidence supporting an opposing role: that FcεRI on DCs instead promotes immune homeostasis and regulation. In this review, we will update the current status of our understanding of FcεRI biology and function, with a specific focus on DCs and monocytes. Springer Basel, 2015 High affinity IgE receptor nationallicence FcεRI nationallicence Dendritic cell nationallicence Monocyte nationallicence Endocytosis nationallicence Signaling nationallicence Antigen presentation nationallicence Shin Jeoung-Sook Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, 513 Parnassus Avenue, HSE-201, 94143, San Francisco, CA, USA aut Greer Alexandra Department of Infectious Disease, Genentech, Inc., South San Francisco, CA, USA aut Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2349-2360 1420-682X 72:12<2349 2015 72 18 https://doi.org/10.1007/s00018-015-1870-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1870-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin Jeoung-Sook Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, 513 Parnassus Avenue, HSE-201, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Greer Alexandra Department of Infectious Disease, Genentech, Inc., South San Francisco, CA, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2349-2360 1420-682X 72:12<2349 2015 72 18