caa a22 4500 606175601 CHVBK 20210128100743.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00018-015-1864-8 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1864-8 Transcription factors and target genes of pre-TCR signaling [Elektronische Daten] [Cristina López-Rodríguez, Jose Aramburu, Rosa Berga-Bolaños] Almost 30years ago pioneering work by the laboratories of Harald von Boehmer and Susumo Tonegawa provided the first indications that developing thymocytes could assemble a functional TCRβ chain-containing receptor complex, the pre-TCR, before TCRα expression. The discovery and study of the pre-TCR complex revealed paradigms of signaling pathways in control of cell survival and proliferation, and culminated in the recognition of the multifunctional nature of this receptor. As a receptor integrated in a dynamic developmental process, the pre-TCR must be viewed not only in the light of the biological outcomes it promotes, but also in context with those molecular processes that drive its expression in thymocytes. This review article focuses on transcription factors and target genes activated by the pre-TCR to drive its different outcomes. Springer Basel, 2015 Thymocyte development nationallicence Pre-TCR expression nationallicence Pre-TCR signaling nationallicence Transcription factor nationallicence Gene expression nationallicence NF-κB nationallicence NFATc nationallicence NFAT5 nationallicence ETS1 nationallicence E2A/HEB proteins nationallicence Bcl2A1 nationallicence p53 nationallicence Intrinsic apoptotic pathway nationallicence López-Rodríguez Cristina Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park, Universitat Pompeu Fabra, C/Doctor Aiguader Nº88, 08003, Barcelona, Barcelona, Spain aut Aramburu Jose Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park, Universitat Pompeu Fabra, C/Doctor Aiguader Nº88, 08003, Barcelona, Barcelona, Spain aut Berga-Bolaños Rosa Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park, Universitat Pompeu Fabra, C/Doctor Aiguader Nº88, 08003, Barcelona, Barcelona, Spain aut Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2305-2321 1420-682X 72:12<2305 2015 72 18 https://doi.org/10.1007/s00018-015-1864-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1864-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- López-Rodríguez Cristina Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park, Universitat Pompeu Fabra, C/Doctor Aiguader Nº88, 08003, Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Aramburu Jose Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park, Universitat Pompeu Fabra, C/Doctor Aiguader Nº88, 08003, Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Berga-Bolaños Rosa Immunology Unit, Department of Experimental and Health Sciences and Barcelona Biomedical Research Park, Universitat Pompeu Fabra, C/Doctor Aiguader Nº88, 08003, Barcelona, Barcelona, Spain aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/12(2015-06-01), 2305-2321 1420-682X 72:12<2305 2015 72 18