caa a22 4500 606175644 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-2011-2 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2011-2 Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer [Elektronische Daten] [Nisha Durand, Sahra Borges, Peter Storz] The protein kinase D (PKD) family members, PKD1, PKD2 and PKD3 constitute a family of serine/threonine kinases that are essential regulators of cell migration, proliferation and protein transport. Multiple types of cancers are characterized by aberrant expression of PKD isoforms. In breast cancer PKD isoforms exhibit distinct expression patterns and regulate various oncogenic processes. In highly invasive breast cancer, the leading cause of cancer-associated deaths in females, the loss of PKD1 is thought to promote invasion and metastasis, while PKD2 and upregulated PKD3 have been shown to be positive regulators of proliferation, chemoresistance and metastasis. In this review, we examine the differential expression pattern, mechanisms of regulation and contributions made by each PKD isoform to the development and maintenance of invasive breast cancer. In addition, we discuss the potential therapeutic approaches for targeting PKD in this disease. Springer Basel, 2015 Protein kinase D nationallicence PKD nationallicence Invasive breast cancer nationallicence Invasion nationallicence Multi-drug resistance nationallicence CaMK : Calcium/calmodulin-dependent kinase nationallicence CML : Chronic myelogenous leukemia nationallicence S6K1 : S6 Kinase 1 nationallicence DMTI : DNA methyltransferase inhibitors nationallicence EGFR : Epidermal growth factor receptor nationallicence EMT : Epithelial to mesenchymal transition nationallicence ER : Estrogen receptor nationallicence ERE : Estrogen response element nationallicence GABP : GA-binding protein nationallicence GIT1 : G-protein-coupled receptor kinase-interacting protein 1 nationallicence IDC : Invasive ductal carcinoma nationallicence LIMK : LIM domain kinase nationallicence MMP : Matrix metalloproteinase nationallicence mTORC1 : Mammalian target of rapamycin complex 1 nationallicence PAK4 : p21-activated kinase 4 nationallicence PDZ : Postsynaptic density 95/Discs large/zona occludens 1 nationallicence PKC : Protein kinase C nationallicence PKD : Protein kinase D nationallicence RIN1 : Ras and Rab interactor 1 nationallicence SSH1L : Slingshot 1L nationallicence TNBC : Triple-negative breast cancer nationallicence Durand Nisha Department of Cancer Biology, Mayo Clinic, Griffin Room 306, 4500 San Pablo Road, 32224, Jacksonville, FL, USA aut Borges Sahra Department of Cancer Biology, Mayo Clinic, Griffin Room 306, 4500 San Pablo Road, 32224, Jacksonville, FL, USA aut Storz Peter Department of Cancer Biology, Mayo Clinic, Griffin Room 306, 4500 San Pablo Road, 32224, Jacksonville, FL, USA aut Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4369-4382 1420-682X 72:22<4369 2015 72 18 https://doi.org/10.1007/s00018-015-2011-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2011-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Durand Nisha Department of Cancer Biology, Mayo Clinic, Griffin Room 306, 4500 San Pablo Road, 32224, Jacksonville, FL, USA aut NATIONALLICENCE 700 1- Borges Sahra Department of Cancer Biology, Mayo Clinic, Griffin Room 306, 4500 San Pablo Road, 32224, Jacksonville, FL, USA aut NATIONALLICENCE 700 1- Storz Peter Department of Cancer Biology, Mayo Clinic, Griffin Room 306, 4500 San Pablo Road, 32224, Jacksonville, FL, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4369-4382 1420-682X 72:22<4369 2015 72 18