caa a22 4500 606175679 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-2008-x doi (NATIONALLICENCE)springer-10.1007/s00018-015-2008-x Timoshenko Alexander Department of Biology, Western University, 1151 Richmond Street, N6A 5B7, London, ON, Canada aut Towards molecular mechanisms regulating the expression of galectins in cancer cells under microenvironmental stress conditions [Elektronische Daten] [Alexander Timoshenko] Galectins, a family of soluble β-galactoside-binding proteins, serve as mediators of fundamental biological processes, such as cell growth, differentiation, adhesion, migration, survival, and death. The purpose of this review is to summarize the current knowledge regarding the ways in which the expression of individual galectins differs in normal and transformed human cells exposed to various stimuli mimicking physiological and pathological microenvironmental stress conditions. A conceptual point is being made and grounded that the modulation of galectin expression profiles is a key aspect of cellular stress responses. Moreover, this modulation might be precisely regulated at transcriptional and post-transcriptional levels in the context of non-overlapping transcription factors and miRNAs specific to galectins. Springer Basel, 2015 Galectins nationallicence Cellular stress responses nationallicence Hypoxia nationallicence Cancer nationallicence Apoptosis nationallicence Cell survival nationallicence Transcription factors nationallicence miRNA nationallicence Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4327-4340 1420-682X 72:22<4327 2015 72 18 https://doi.org/10.1007/s00018-015-2008-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2008-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Timoshenko Alexander Department of Biology, Western University, 1151 Richmond Street, N6A 5B7, London, ON, Canada aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4327-4340 1420-682X 72:22<4327 2015 72 18