caa a22 4500 606175695 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-2005-0 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2005-0 Human dendritic cell subsets and function in health and disease [Elektronische Daten] [Meredith O'Keeffe, Wai Mok, Kristen Radford] The method of choice for the development of new vaccines is to target distinct dendritic cell subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated immunity or induce tolerance to specific antigens. The innate functions of dendritic cells themselves may also be targeted by inhibitors or activators that would target a specific function such as interferon production, potentially important in autoimmune disease and chronic viral infections. Importantly targeting dendritic cells requires detailed knowledge of both the surface phenotype and function of each dendritic cell subset, including how they may respond to different types of vaccine adjuvants, their ability to produce soluble mediators and to process and present antigens and induce priming of naïve T cells. This review summarizes our knowledge of the functional attributes of the human dendritic cell subsets in the steady state and upon activation and their roles in human disease. Springer Basel, 2015 Human dendritic cells nationallicence CD141+ dendritic cells nationallicence CD1c+ dendritic cells nationallicence Plasmacytoid dendritic cells nationallicence Cytokines nationallicence Innate immunity nationallicence Interferons nationallicence Antigen presentation nationallicence Ag : Antigen nationallicence CTL : Cytotoxic T lymphocyte nationallicence DC : Dendritic cells nationallicence ESAM : Endothelial cell-selective adhesion molecule nationallicence Flt3 : Fms-like tyrosine kinase 3 nationallicence Flt3L : Fms-like tyrosine kinase 3 ligand nationallicence HCV : Hepatitis C virus nationallicence IFN : Interferon nationallicence IFN-I : Type I interferons nationallicence IFN-III : Type III interferons (also known as IFN-λ) nationallicence LC : Langerhans cells nationallicence MoDC : Monocytes-derived dendritic cells nationallicence Necl2 : Nectin-like protein 2 nationallicence NET : Neutrophil extracellular trap nationallicence PDC : Plasmacytoid dendritic cells nationallicence PAMPs or DAMPs : Pathogen or damage associated molecular patterns nationallicence PBMC : Peripheral blood mononuclear cells nationallicence Poly I:C : Polyinosinic:polycytidylic acid nationallicence PRR : Pattern recognition receptors nationallicence SLE : Systemic lupus erythematosus nationallicence SNP : Single nucleotide polymorphism nationallicence TGF : Transforming growth factor nationallicence TLR : Toll-like receptor nationallicence TSLP : Thymic stromal lymphopoietin nationallicence TNF : Tumor necrosis factor nationallicence O'Keeffe Meredith Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, 3004, Melbourne, VIC, Australia aut Mok Wai Mater Research Institute, University of Queensland, 37 Kent St, 4012, Woolloongabba, QLD, Australia aut Radford Kristen Mater Research Institute, University of Queensland, 37 Kent St, 4012, Woolloongabba, QLD, Australia aut Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4309-4325 1420-682X 72:22<4309 2015 72 18 https://doi.org/10.1007/s00018-015-2005-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2005-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Keeffe Meredith Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, 3004, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Mok Wai Mater Research Institute, University of Queensland, 37 Kent St, 4012, Woolloongabba, QLD, Australia aut NATIONALLICENCE 700 1- Radford Kristen Mater Research Institute, University of Queensland, 37 Kent St, 4012, Woolloongabba, QLD, Australia aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4309-4325 1420-682X 72:22<4309 2015 72 18