caa a22 4500 606175725 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00018-015-2001-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-2001-4 Emerging roles of lysine methylation on non-histone proteins [Elektronische Daten] [Xi Zhang, Yaling Huang, Xiaobing Shi] Lysine methylation is a common posttranslational modification (PTM) of histones that is important for the epigenetic regulation of transcription and chromatin in eukaryotes. Increasing evidence demonstrates that in addition to histones, lysine methylation also occurs on various non-histone proteins, especially transcription- and chromatin-regulating proteins. In this review, we will briefly describe the histone lysine methyltransferases (KMTs) that have a broad spectrum of non-histone substrates. We will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysine methylation and other PTMs in regulating the functions of the modified proteins. Understanding the roles of lysine methylation in normal cells and during development will shed light on the complex biology of diseases associated with the dysregulation of lysine methylation on both histones and non-histone proteins. Springer Basel, 2015 Lysine methylation nationallicence SETD7 nationallicence G9a nationallicence SMYD2 nationallicence p53 nationallicence ERα nationallicence Zhang Xi Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA aut Huang Yaling Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA aut Shi Xiaobing Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA aut Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4257-4272 1420-682X 72:22<4257 2015 72 18 https://doi.org/10.1007/s00018-015-2001-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-2001-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Xi Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Huang Yaling Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Shi Xiaobing Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/22(2015-11-01), 4257-4272 1420-682X 72:22<4257 2015 72 18