caa a22 4500 606175830 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1940-0 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1940-0 MicroRNA: master controllers of intracellular signaling pathways [Elektronische Daten] [Pak-Yin Lui, Dong-Yan Jin, Nigel Stevenson] Signaling pathways are essential intracellular networks that coordinate molecular outcomes to external stimuli. Tight regulation of these pathways is essential to ensure an appropriate response. MicroRNA (miRNA) is a class of small, non-coding RNA that regulates gene expression at a post-transcriptional level by binding to the complementary sequence on target mRNA, thus limiting protein translation. Intracellular pathways are controlled by protein regulators, such as suppressor of cytokine signaling and A20. Until recently, expression of these classical protein regulators was thought to be controlled solely by transcriptional induction and proteasomal degradation; however, there is a growing body of evidence describing their regulation by miRNA. This new information has transformed our understanding of cell signaling by adding a previously unknown layer of regulatory control. This review outlines the miRNA regulation of these classical protein regulators and describes their broad effects at both cellular and disease levels. We review the regulation of three important signaling pathways, including the JAK/STAT, NF-κB, and TGF-β pathways, and summarize an extensive catalog of their regulating miRNAs. This information highlights the importance of the miRNA regulon and reveals a previously unknown regulatory landscape that must be included in the identification and development of novel therapeutic targets for clinical disorders. Springer Basel, 2015 MicroRNA nationallicence Signal regulator nationallicence Regulon nationallicence JAK-STAT nationallicence NF-κB nationallicence TGF-β nationallicence Transcriptome-wide nationallicence Lui Pak-Yin Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong aut Jin Dong-Yan Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong aut Stevenson Nigel School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland aut Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3531-3542 1420-682X 72:18<3531 2015 72 18 https://doi.org/10.1007/s00018-015-1940-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1940-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lui Pak-Yin Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong aut NATIONALLICENCE 700 1- Jin Dong-Yan Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong aut NATIONALLICENCE 700 1- Stevenson Nigel School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3531-3542 1420-682X 72:18<3531 2015 72 18