caa a22 4500 606175849 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1920-4 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1920-4 Cancer stem cells: a potential target for cancer therapy [Elektronische Daten] [Hong Qiu, Xiaoguang Fang, Qi Luo, Gaoliang Ouyang] Current evidence indicates that a subpopulation of cancer cells, named cancer stem cells (CSCs) or tumor-initiating cells, are responsible for the initiation, growth, metastasis, therapy resistance and recurrence of cancers. CSCs share core regulatory pathways with normal stem cells; however, CSCs rely on distinct reprogrammed pathways to maintain stemness and to contribute to the progression of cancers. The specific targeting of CSCs, together with conventional chemotherapy or radiotherapy, may achieve stable remission or cure cancer. Therefore, the identification of CSCs and a better understanding of the complex characteristics of CSCs will provide invaluable diagnostic, therapeutic and prognostic targets for clinical application. In this review, we will introduce the dysregulated properties of CSCs in cancers and discuss the possible challenges in targeting CSCs for cancer treatment. Springer Basel, 2015 Cancer-initiating cell nationallicence Self-renewal nationallicence Tumorigenesis nationallicence Tumor metastasis nationallicence Qiu Hong State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, China aut Fang Xiaoguang State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, China aut Luo Qi Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, 361003, Xiamen, China aut Ouyang Gaoliang State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, China aut Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3411-3424 1420-682X 72:18<3411 2015 72 18 https://doi.org/10.1007/s00018-015-1920-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1920-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qiu Hong State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, China aut NATIONALLICENCE 700 1- Fang Xiaoguang State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, China aut NATIONALLICENCE 700 1- Luo Qi Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, 361003, Xiamen, China aut NATIONALLICENCE 700 1- Ouyang Gaoliang State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, 361102, Xiamen, China aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3411-3424 1420-682X 72:18<3411 2015 72 18