caa a22 4500 606175857 CHVBK 20210128100744.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1939-6 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1939-6 The code of non-coding RNAs in lung fibrosis [Elektronische Daten] [Huachun Cui, Na Xie, Victor Thannickal, Gang Liu] The pathogenesis of pulmonary fibrosis is a complicated and complex process that involves phenotypic abnormalities of a variety of cell types and dysregulations of multiple signaling pathways. There are numerous genetic, epigenetic and post-transcriptional mechanisms that have been identified to participate in the pathogenesis of this disease. However, efficacious therapeutics developed from these studies have been disappointingly limited. In the past several years, a group of new molecules, i.e., non-coding RNAs (ncRNAs), has been increasingly appreciated to have critical roles in the pathological progression of lung fibrosis. In this review, we summarize the recent findings on the roles of ncRNAs in the pathogenesis of this disorder. We analyze the translational potential of this group of molecules in treating lung fibrosis. We also discuss challenges and future opportunities of studying and utilizing ncRNAs in lung fibrosis. Springer Basel, 2015 Idiopathic pulmonary fibrosis (IPF) nationallicence microRNA nationallicence Long non-coding RNA (lncRNA) nationallicence Cui Huachun Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut Xie Na Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut Thannickal Victor Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut Liu Gang Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3507-3519 1420-682X 72:18<3507 2015 72 18 https://doi.org/10.1007/s00018-015-1939-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1939-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cui Huachun Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Xie Na Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Thannickal Victor Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Liu Gang Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, 901 19th St. So., BMR II 233, 35294, Birmingham, AL, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3507-3519 1420-682X 72:18<3507 2015 72 18