caa a22 4500 606175873 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00018-015-1936-9 doi (NATIONALLICENCE)springer-10.1007/s00018-015-1936-9 The short and long of noncoding sequences in the control of vascular cell phenotypes [Elektronische Daten] [Joseph Miano, Xiaochun Long] The two principal cell types of importance for normal vessel wall physiology are smooth muscle cells and endothelial cells. Much progress has been made over the past 20years in the discovery and function of transcription factors that coordinate proper differentiation of these cells and the maintenance of vascular homeostasis. More recently, the converging fields of bioinformatics, genomics, and next generation sequencing have accelerated discoveries in a number of classes of noncoding sequences, including transcription factor binding sites (TFBS), microRNA genes, and long noncoding RNA genes, each of which mediates vascular cell differentiation through a variety of mechanisms. Alterations in the nucleotide sequence of key TFBS or deviations in transcription of noncoding RNA genes likely have adverse effects on normal vascular cell phenotype and function. Here, the subject of noncoding sequences that influence smooth muscle cell or endothelial cell phenotype will be summarized as will future directions to further advance our understanding of the increasingly complex molecular circuitry governing normal vascular cell differentiation and how such information might be harnessed to combat vascular diseases. Springer Basel, 2015 microRNA nationallicence Long noncoding RNA nationallicence Transcription factor binding site nationallicence Smooth muscle cell nationallicence Endothelial cell nationallicence Differentiation nationallicence CRISPR : Clustered regularly interspaced short palindromic repeats nationallicence EC : Endothelial cell nationallicence ENCODE : Encyclopedia of DNA Elements nationallicence ETS : E26 transformation specific nationallicence LncRNA : Long noncoding RNA nationallicence LSS : Laminar shear stress nationallicence Mir : MicroRNA nationallicence MYOCD : Myocardin nationallicence NAT : Natural antisense transcript nationallicence NICD : Notch intracellular domain nationallicence RACE : Rapid amplification of cDNA ends nationallicence SMC : Smooth muscle cell nationallicence SNP : Single nucleotide polymorphism nationallicence SRF : Serum response factor nationallicence TFBS : Transcription factor binding site nationallicence Miano Joseph Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, 14642, Rochester, NY, USA aut Long Xiaochun Center for Cardiovascular Sciences, Albany Medical College, 12208, Albany, NY, USA aut Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3457-3488 1420-682X 72:18<3457 2015 72 18 https://doi.org/10.1007/s00018-015-1936-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-015-1936-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miano Joseph Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, 14642, Rochester, NY, USA aut NATIONALLICENCE 700 1- Long Xiaochun Center for Cardiovascular Sciences, Albany Medical College, 12208, Albany, NY, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/18(2015-09-01), 3457-3488 1420-682X 72:18<3457 2015 72 18