caa a22 4500 60617592X CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00018-014-1760-7 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1760-7 Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse [Elektronische Daten] [Audrey Le Floc'h, Morgan Huse] Transient,specialized cell-cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. Springer Basel, 2014 Cytoskeleton nationallicence Actin nationallicence T cells nationallicence Immunological synapse nationallicence T cell receptor nationallicence Cytotoxicity nationallicence Signal transduction nationallicence Le Floc'h Audrey Immunology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 514, 10065, New York, NY, USA aut Huse Morgan Immunology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 514, 10065, New York, NY, USA aut Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 537-556 1420-682X 72:3<537 2015 72 18 https://doi.org/10.1007/s00018-014-1760-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1760-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Floc'h Audrey Immunology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 514, 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Huse Morgan Immunology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Box 514, 10065, New York, NY, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 537-556 1420-682X 72:3<537 2015 72 18