caa a22 4500 606175954 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00018-014-1759-0 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1759-0 The gene regulatory networks underlying formation of the auditory hindbrain [Elektronische Daten] [Marc Willaredt, Tina Schlüter, Hans Nothwang] Development and evolution of auditory hindbrain nuclei are two major unsolved issues in hearing research. Recent characterization of transgenic mice identified the rhombomeric origins of mammalian auditory nuclei and unraveled genes involved in their formation. Here, we provide an overview on these data by assembling them into rhombomere-specific gene regulatory networks (GRNs), as they underlie developmental and evolutionary processes. To explore evolutionary mechanisms, we compare the GRNs operating in the mammalian auditory hindbrain with data available from the inner ear and other vertebrate groups. Finally, we propose that the availability of genomic sequences from all major vertebrate taxa and novel genetic techniques for non-model organisms provide an unprecedented opportunity to investigate development and evolution of the auditory hindbrain by comparative molecular approaches. The dissection of the molecular mechanisms leading to auditory structures will also provide an important framework for auditory processing disorders, a clinical problem difficult to tackle so far. These data will, therefore, foster basic and clinical hearing research alike. Springer Basel, 2014 Auditory hindbrain nationallicence Bird nationallicence Development nationallicence Evolution nationallicence Mammalia nationallicence Novelty nationallicence Rhombomere nationallicence Transcription factor nationallicence Signaling nationallicence Auditory processing disorders nationallicence A-P : Anterior-posterior nationallicence AVCN : Anterior ventral cochlear nucleus nationallicence BMP : Bone morphogenetic protein nationallicence CNC : Cochlear nucleus complex nationallicence DCN : Dorsal cochlear nucleus nationallicence E : Embryonic nationallicence LSO : Lateral superior olive nationallicence MNTB : Medial nucleus of the trapezoid body nationallicence NA : Nucleus angularis nationallicence NL : Nucleus laminaris nationallicence NLL : Nucleus of the lateral lemniscus nationallicence NM : Nucleus magnocellularis nationallicence P : Postnatal nationallicence PVCN : Posterior ventral cochlear nucleus nationallicence r : Rhombomere nationallicence RA : Retinoic acid nationallicence SOC : Superior olivary complex nationallicence TF : Transcription factor nationallicence Willaredt Marc Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany aut Schlüter Tina Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany aut Nothwang Hans Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany aut Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 519-535 1420-682X 72:3<519 2015 72 18 https://doi.org/10.1007/s00018-014-1759-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1759-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willaredt Marc Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany aut NATIONALLICENCE 700 1- Schlüter Tina Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany aut NATIONALLICENCE 700 1- Nothwang Hans Neurogenetics group, Center of Excellence Hearing4All, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26111, Oldenburg, Germany aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 519-535 1420-682X 72:3<519 2015 72 18