caa a22 4500 606175962 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00018-014-1740-y doi (NATIONALLICENCE)springer-10.1007/s00018-014-1740-y Dynamic droplets: the role of cytoplasmic inclusions in stress, function, and disease [Elektronische Daten] [Triana Amen, Daniel Kaganovich] Neurodegenerative diseases and other proteinopathies constitute a class of several dozen illnesses etiologically linked to pathological protein misfolding and aggregation. Because of this strong association with disease pathology, cell death, and aging, accumulation of proteins in aggregates or aggregation-associated structures (inclusions) has come to be regarded by many as a deleterious process, to be avoided if possible. Recent work has led us to see inclusion structures and disordered aggregate-like protein mixtures (which we call dynamic droplets) in a new light: not necessarily as a result of a pathological breakdown of cellular order, but as an elaborate cellular architecture regulating function and stress response. In this review, we discuss what is currently known about the role of inclusion structures in cellular homeostasis, stress response, toxicity, and disease. We will focus on possible mechanisms of aggregate toxicity, in contrast to the homeostatic function of several inclusion structures. Springer Basel, 2014 Chaperone nationallicence Ubiquitin nationallicence Proteasome nationallicence Misfolded protein nationallicence Aggregation nationallicence PhoC nationallicence Inclusion nationallicence Inclusion body nationallicence Aggresome nationallicence JUNQ nationallicence IPOD nationallicence Stress foci nationallicence Stress granules nationallicence P-bodies nationallicence Dynamic droplets nationallicence Amen Triana Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel aut Kaganovich Daniel Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel aut Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 401-415 1420-682X 72:3<401 2015 72 18 https://doi.org/10.1007/s00018-014-1740-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1740-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amen Triana Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel aut NATIONALLICENCE 700 1- Kaganovich Daniel Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 401-415 1420-682X 72:3<401 2015 72 18