caa a22 4500 606175997 CHVBK 20210128100745.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00018-014-1757-2 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1757-2 Cell death controlling complexes and their potential therapeutic role [Elektronische Daten] [Alexey Zamaraev, Gelina Kopeina, Boris Zhivotovsky, Inna Lavrik] Programmed cell death plays a central role in the regulation of homeostasis and development of multicellular organisms. Deregulation of programmed cell death is connected to a number of disorders, including cancer and autoimmune diseases. Initiation of cell death occurs in the multiprotein complexes or high molecular weight platforms. Composition, structure, and molecular interactions within these platforms influence the cellular decision toward life or death and, therefore, define the induction of a particular cell death program. Here, we discuss in detail the key cell-death complexes—including DISC, complex II, and TNFRI complex I/II, and the necrosome, RIPoptosome, apoptosome, and PIDDosome—that control apoptosis or necroptosis pathways as well as their regulation. The possibility of their pharmacological targeting leading to the development of new strategies of interference with cell death programs via control of the high molecular weight platforms will be discussed. Springer Basel, 2014 Cell death nationallicence Protein complexes nationallicence DISC nationallicence Apoptosome nationallicence PIDDosome nationallicence RIPoptosome nationallicence Caspases nationallicence Zamaraev Alexey Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Kopeina Gelina Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Zhivotovsky Boris Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Lavrik Inna Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 505-517 1420-682X 72:3<505 2015 72 18 https://doi.org/10.1007/s00018-014-1757-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1757-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zamaraev Alexey Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Kopeina Gelina Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Zhivotovsky Boris Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Lavrik Inna Faculty of Basic Medicine, MV Lomonosov Moscow State University, 119991, Moscow, Russia aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/3(2015-02-01), 505-517 1420-682X 72:3<505 2015 72 18